Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance

被引：28

作者：

Parvaiz, Fahed ^{[1
]}

Manzoor, Sobia ^{[1
]}

Tariq, Huma ^{[1
]}

Javed, Farakh ^{[1
]}

Fatima, Kaneez ^{[1
]}

Qadri, Ishtiaq ^{[1
]}

机构：

[1] Natl Univ Sci & Technol, NUST Ctr Virol & Immunol, Islamabad 44000, Pakistan

来源：

VIROLOGY JOURNAL | 2011年 / 8卷

关键词：

HCV Infection; Molecular Pathways; Insulin Resistance; PROTEIN PHOSPHATASE 2A; CORE PROTEIN; RECEPTOR SUBSTRATE-1; DIABETES-MELLITUS; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; SIGNALING PATHWAY; VIRAL-HEPATITIS; NADPH OXIDASE;

D O I：

10.1186/1743-422X-8-474

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic Hepatitis C virus has the potential of inducing insulin resistance and type 2 Diabetes Mellitus in vitro as well as in vivo. Structural and non-structural proteins of HCV modulate cellular gene expression in such a way that insulin signaling is hampered, concomitantly leads toward diabetes mellitus. A number of mechanisms have been proposed in regard to the HCV induced insulin resistance involving the upregulation of Inflammatory cytokine TNF-alpha, hypophosphorylation of IRS-1 and IRS-2, phosphorylation of Akt, up-regulation of gluconeogenic genes, accumulation of lipids and targeting lipid storage organelles. This review provides an insight of molecular mechanisms by which HCV structural and non-structural proteins can induce insulin resistance.

引用

页数：6

共 50 条

[41] Insulin resistance and steatosis in chronic hepatitis C [J].

Machado, Mariana V. ;

Cortez-Pinto, Helena .

ANNALS OF HEPATOLOGY, 2009, 8 :S67-S75

[42] Pathomechanism of insulin resistance in chronic hepatitis C [J].

Kukla, Michal ;

Sawczyn, Tomasz ;

Zwirska-Korczala, Krystyna ;

Jarosz, Miroslaw .

PRZEGLAD GASTROENTEROLOGICZNY, 2011, 6 (05) :284-289

[43] Hepatitis C virus infection is associated with insulin resistance among older adults with or at risk of HIV infection [J].

Howard, Andrea A. ;

Lo, Yungtai ;

Floris-Moore, Michelle ;

Klein, Robert S. ;

Fleischer, Norman ;

Schoenbaum, Ellie E. .

AIDS, 2007, 21 (05) :633-641

[44] Insulin resistance and hepatitis C: an evolving story [J].

Eslam, Mohammed ;

Khattab, Mahmoud AboElneen ;

Harrison, Stephen A. .

GUT, 2011, 60 (08) :1139-1151

[45] Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection [J].

Chao-Hung Hung ;

Jing-Houng Wang ;

Tsung-Hui Hu ;

Chien-Hung Chen ;

Kuo-Chin Chang ;

Yi-Hao Yen ;

YuanHung Kuo ;

Ming-Chao Tsai ;

Chuan-Mo Lee .

World Journal of Gastroenterology, 2010, 16 (18) :2265-2271

[46] Chronic hepatitis C infection is associated with insulin resistance and lipid profiles [J].

Dai, Chia-Yen ;

Yeh, Ming-Lun ;

Huang, Chung-Feng ;

Hou, Chen-Hsiu ;

Hsieh, Ming-Yen ;

Huang, Jee-Fu ;

Lin, I-Ling ;

Lin, Zu-Yau ;

Chen, Shinn-Chern ;

Wang, Liang-Yen ;

Chuang, Wan-Long ;

Yu, Ming-Lung ;

Tung, Hung-Da .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2015, 30 (05) :879-884

[47] Insulin Resistance Provides the Connection Between Hepatitis C Virus and Diabetes [J].

Safi, Sher Zaman ;

Shah, Humaira ;

Yan, Gracie Ong Siok ;

Qvist, Rajes .

HEPATITIS MONTHLY, 2015, 15 (01)

[48] Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure [J].

Lim, Teegan R. ;

Hazlehurst, Jonathan M. ;

Oprescu, Andrei, I ;

Armstron, Matthew J. ;

Abdullah, Sewa F. ;

Davies, Nigel P. ;

Flintham, Robert ;

Balfe, Peter ;

Mutimer, David J. ;

McKeating, Jane A. ;

Tomlinson, Jeremy W. .

CLINICAL ENDOCRINOLOGY, 2019, 90 (03) :440-448

[49] Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease [J].

Oono, Takashi ;

Yamasaki, Takahiro ;

Zaitsu, Junichi ;

Saeki, Issei ;

Iwamoto, Takuya ;

Harima, Yumiko ;

Marumoto, Yoshio ;

Hidaka, Isao ;

Urata, Yohei ;

Ishikawa, Tsuyoshi ;

Takami, Taro ;

Segawa, Makoto ;

Uchida, Koichi ;

Terai, Shuji ;

Kunitugu, Ichiro ;

Tanabe, Tsuyoshi ;

Sakaida, Isao .

HEPATOLOGY RESEARCH, 2014, 44 (10) :E54-E62

[50] Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studies [J].

Badar, Sadaf ;

Khubaib, Bushra ;

Idrees, Muhammad ;

Hussain, Abrar ;

Awan, Zunaira ;

Butt, Sadia ;

Afzal, Samia ;

Akram, Madeeha ;

Fatima, Zareen ;

Aftab, Mahwish ;

Saleem, Sana ;

Munir, Sara ;

Rauff, Bisma ;

Naudhani, Mahrukh ;

Ali, Liaquat ;

Ali, Muhammaad ;

Irshad-ul-Rehman .

HEPATITIS MONTHLY, 2012, 12 (01) :11-15

← 1 2 3 4 5 →