Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance

被引：27
|
作者：
Parvaiz, Fahed [1 ]
Manzoor, Sobia [1 ]
Tariq, Huma [1 ]
Javed, Farakh [1 ]
Fatima, Kaneez [1 ]
Qadri, Ishtiaq [1 ]
机构：
[1] Natl Univ Sci & Technol, NUST Ctr Virol & Immunol, Islamabad 44000, Pakistan
来源：
VIROLOGY JOURNAL | 2011年 / 8卷
关键词：
HCV Infection; Molecular Pathways; Insulin Resistance; PROTEIN PHOSPHATASE 2A; CORE PROTEIN; RECEPTOR SUBSTRATE-1; DIABETES-MELLITUS; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; SIGNALING PATHWAY; VIRAL-HEPATITIS; NADPH OXIDASE;
D O I：
10.1186/1743-422X-8-474
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chronic Hepatitis C virus has the potential of inducing insulin resistance and type 2 Diabetes Mellitus in vitro as well as in vivo. Structural and non-structural proteins of HCV modulate cellular gene expression in such a way that insulin signaling is hampered, concomitantly leads toward diabetes mellitus. A number of mechanisms have been proposed in regard to the HCV induced insulin resistance involving the upregulation of Inflammatory cytokine TNF-alpha, hypophosphorylation of IRS-1 and IRS-2, phosphorylation of Akt, up-regulation of gluconeogenic genes, accumulation of lipids and targeting lipid storage organelles. This review provides an insight of molecular mechanisms by which HCV structural and non-structural proteins can induce insulin resistance.
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页数：6
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