Palladium-Catalyzed Three-Component Cascade Reaction: Facial Access to Densely Functionalized Indolizines

被引：33

作者：

Liu, Ren-Rong ^{[1
]}

Lu, Chuan-Jun ^{[1
]}

Zhang, Ming-Di ^{[1
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 19期

关键词：

cascade reactions; cyclization; enynes; heterocycles; palladium; C-H ACTIVATION; EFFICIENT SYNTHESIS; TETRASUBSTITUTED FURANS; DOMINO REACTIONS; HIGHLY REGIO; MULTICOMPONENT REACTIONS; SYNTHETIC APPLICATION; CYCLIZATION REACTION; 2,3-ALLENOIC ACIDS; COUPLING REACTION;

D O I：

10.1002/chem.201500569

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed three-component cascade reaction of 2-(2-enynyl)pyridines with nucleophiles and allyl halides has been developed, enabling the synthesis of densely functionalized indolizines in moderate to good yields. The newly developed methodology offers several practical advantages, including operational simplicity, ready availability of starting materials, and mild reaction conditions.

引用

页码：7057 / 7060

页数：4

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