In this theoretical study, a fully developed laminar convective water flow in a circular tube is "convectively overloaded" toward the microscale, by decreasing the tube diameter below 1 mm. The entropy generation rate ((S) over dot(gen)) is obtained (with and without the viscous dissipation term) for a given rate of heat removal using a fixed rate of coolant (water) flow. The uniform wall heat flux and mass flux in a tube increase toward the micro-scale, which is "thermal and flow overloading," respectively. The variations of-(S) over dot(gen) due to fluid friction, fluid conduction heat transfer, and their total ((S) over dot(gen,tot)), toward the micro-scale, are analyzed. Since (S) over dot(gen,tot) remains more or less the same toward the microscale, it is worth overloading a tube for miniaturization up to the laminar-flow limit.