Hyaluronic acid-Based wound dressings: A review

被引：591
作者：
Graca, Mariana F. P. [1 ]
Miguel, Sonia P. [1 ,2 ]
Cabral, Catia S. D. [1 ]
Correia, Ilidio J. [1 ,3 ]
机构：
[1] Univ Beira Interior, CICS UBI Ctr Invest Ciancias Saude, Av Infante D Henrique, P-6200506 Covilha, Portugal
[2] Inst Politecn Guarda, CPIRN IPG Ctr Potential & Inovacao Recursos Nat, Av Dr Francisco de Sa Carneiro, P-6300559 Guarda, Portugal
[3] Univ Coimbra, CIEPQPF Dept Engn Quim, Rua Silvio Lima, P-3030790 Coimbra, Portugal
来源：
CARBOHYDRATE POLYMERS | 2020年 / 241卷
关键词：
Hyaluronic acid; Wound dressing; Wound healing; DEGRADABLE MULTILAYER FILMS; GROWTH-FACTOR; COLLAGEN/HYALURONIC ACID; (HA)-BASED HYDROGELS; COMPOSITE HYDROGELS; COLLAGEN SPONGE; DRUG-DELIVERY; DERIVATIVES; SCAFFOLDS; DIFFERENTIATION;
D O I：
10.1016/j.carbpol.2020.116364
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a major component of skin extracellular matrix (ECM) and it is involved in the inflammatory response, angiogenesis, and tissue regeneration process. Due to the intrinsic properties of HA (such as biocompatibility, biodegradability and hydrophilic character), it has been used to produce different wound dressings, namely sponges, films, hydrogels, and electrospun membranes. Herein, an overview of the different HA-based wound dressings that have been produced so far is provided as well as the future directions regarding the strategies aimed to improve the mechanical stability of HA-based wound dressings, along with the incorporation of biomolecules intended to ameliorate their biological performance during the healing process.
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页数：17
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