Injectable cationic hydrogels with high antibacterial activity and low toxicity

被引：42
作者：
Du, Hong [1 ]
Wang, Ying [1 ,2 ]
Yao, Xuxia [3 ]
Luo, Qiaojie [2 ,4 ]
Zhu, Weipu [1 ,5 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Hangzhou 310006, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Mat Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
[5] Key Lab Adsorpt & Separat Mat & Technol Zhejiang, Hangzhou 310027, Zhejiang, Peoples R China
来源：
POLYMER CHEMISTRY | 2016年 / 7卷 / 36期
基金：
中国国家自然科学基金;
关键词：
POLY(ETHYLENE GLYCOL); QUATERNARY-AMMONIUM; CLICK CHEMISTRY; ANTIMICROBIAL HYDROGELS; FACILE FABRICATION; DRUG-RELEASE; NANOPARTICLES; BIOMATERIALS; COPOLYMERS; PREVENTION;
D O I：
10.1039/c6py01346e
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Antibacterial materials have always suffered from high toxicity. In this study, we fabricated injectable and biodegradable hydrogels utilizing poly(hexamethylene guanidine) hydrochloride and poly (ethylene glycol) as the backbone through a thiol-ene "click" reaction under physiological conditions, and they showed remarkably low toxicity and high and broad-spectrum antibacterial activity.
引用
收藏
页码：5620 / 5624
页数：5
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