Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older

被引：15

作者：

Cheval, Boris ^{[1
,2
]}

Csajbok, Zsofia ^{[3
,4
,5
]}

Formanek, Tomas ^{[3
,6
]}

Sieber, Stefan ^{[7
,8
]}

Boisgontier, Matthieu P. ^{[9
,10
]}

Cullati, Stephane ^{[11
,12
]}

Cermakova, Pavla ^{[3
,4
]}

机构：

[1] Univ Geneva, Swiss Ctr Affect Sci, Geneva, Switzerland

[2] Univ Geneva, Dept Psychol, Lab Study Emot Elicitat & Express E3Lab, Geneva, Switzerland

[3] Natl Inst Mental Hlth, Kiecany, Czech Republic

[4] Charles Univ Prague, Fac Med 2, Prague, Czech Republic

[5] Charles Univ Prague, Fac Sci, Prague, Czech Republic

[6] Univ Cambridge, EpiCtr, Dept Psychiat, Cambridge, England

[7] Swiss Ctr Expertise Life Course Res, LIVES Ctr, Carouge, Switzerland

[8] Univ Geneva, Ctr Interdisciplinary Study Gerontol & Vulnerabil, Geneva, Switzerland

[9] Univ Ottawa, Fac Hlth Sci, Sch Rehabil Sci, Ottawa, ON, Canada

[10] Bruyere Res Inst, Ottawa, ON, Canada

[11] Univ Fribourg, Populat Hlth Lab, Fribourg, Switzerland

[12] Univ Geneva, Dept Readaptat & Geriatr, Geneva, Switzerland

来源：

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES | 2021年 / 30卷

基金：

瑞士国家科学基金会; 加拿大自然科学与工程研究理事会; 芬兰科学院;

关键词：

Aging; cognition; longitudinal studies; physical activity; CORONARY-HEART-DISEASE; BRAIN HEALTH; EXERCISE; PARTICIPATION; INTERVENTION; BIOMARKERS; MORTALITY; MEN;

D O I：

10.1017/S2045796021000688

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims To investigate the associations of physical-activity trajectories with the level of cognitive performance (CP) and its decline in adults 50 years of age or older. Methods We studied 38 729 individuals (63 +/- 9 years; 57% women) enrolled in the Survey of Health, Ageing and Retirement in Europe (SHARE). Physical activity was self-reported and CP was assessed based on immediate recall, verbal fluency and delayed recall. Physical-activity trajectories were estimated using growth mixture modelling and linear mixed-effects models were used to investigate the associations between the trajectories and CP. Results The models identified two trajectories of physical activity: constantly high physical activity (N = 27 634: 71%) and decreasing physical activity (N = 11 095; 29%). Results showed that participants in the decreasing physical-activity group exhibited a lower level of CP compared to the high physical-activity group (immediate recall: ss = 0.94; 95% confidence interval [CI] = 0.92-0.95; verbal fluency: ss = 0.98; 95% CI = 0.97-0.98; delayed recall: ss = 0.95; 95% CI = 0.94-0.97). Moreover, compared with participants in the constantly high physical-activity group, participants in the decreasing physical-activity group showed a steeper decline in all cognitive measures (immediate recall: ss = -0.04; 95% CI = -0.05 to -0.04; verbal fluency: ss = -0.22; 95% CI = -0.24 to -0.21; delayed recall: ss = -0.04; 95% CI = -0.05 to -0.04). Conclusions Physical-activity trajectories are associated with the level and evolution of CP in adults over 50 years. Specifically, our findings suggest that a decline in physical activity over multiple years is associated with a lower level and a steeper decline in CP.

引用

页数：10