Recent Advances of 1,3-Dipolar Cycloaddition Chemistry for Alkaloid Synthesis

The synthesis of heterocyclic compounds has attracted significant attention for decades. Among the various heterocycles isolated from nature, alkaloidal natural products have received significant attention due to their diverse bioactivity. As highlighted in this minireview, a growing area of interest in organic synthesis involves the use of substituted 1,3-dipoles for the preparation of different alkaloidal natural products. Cascade reactions proceeding by an intramolecular 1,3-dipolar cycloaddition chemistry are of particular interest to the synthetic organic community because of the increase in molecular complexity involved and the high isolated yields. The synthesis of numerous alkaloids has been elegantly accomplished in recent years using an assortment of synthetic dipole intermediates.