Stereoselective synthesis of vinylogous peptides

被引：41

作者：

Grison, C ^{[1
]}

Genéve, S ^{[1
]}

Halbin, E ^{[1
]}

Coutrot, P ^{[1
]}

机构：

[1] Univ Nancy 1, Inst Nanceien Chim Mol, Lab Chim Organ 2, CNRS,UMR 7565,FR 1742, F-54506 Vandoeuvre Les Nancy, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 23期

关键词：

vinylogous peptides; Horner stereoselective olefination; neuroactive peptides;

D O I：

10.1016/S0040-4020(01)00433-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A trans or cis ethenyl group has been inserted between the alpha -carbon and the carboxyl group of alpha -aminoacids by Horner stereoselective olefination of a-aminoaldehydes. Numerous pure cia and trans vinylogous alpha -aminoacids have been obtained thus and coupled with aminopartners by classical methods. The versatility of the method was illustrated by the preparation of a [trans vinylogous-Gly(3)]Leu-enkephalin. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4903 / 4923

页数：21

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