Mitochondrial compartmentalization of redox processes

被引：68

作者：

Cardoso, Ariel R. ^{[1
]}

Chausse, Bruno ^{[1
]}

da Cunha, Fernanda M. ^{[1
]}

Luevano-Martinez, Luis A. ^{[1
]}

Marazzi, Thire B. M. ^{[1
]}

Pessoa, Phillipe S. ^{[1
]}

Queliconi, Bruno B. ^{[1
]}

Kowaltowski, Alicia J. ^{[1
]}

机构：

[1] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-05508900 Sao Paulo, Brazil

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2012年 / 52卷 / 11-12期

关键词：

Mitochondria; Compartments; Antioxidants; Mitochondrially-targeted probes; Mitochondrially-targeted antioxidants; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; IMAGING HYDROGEN-PEROXIDE; REACTIVE OXYGEN; ELECTRON-TRANSPORT; CYTOCHROME-C; FLUORESCENT-PROBES; MONOAMINE-OXIDASE; SUPEROXIDE ANION; OXIDATIVE STRESS; RAT-LIVER;

D O I：

10.1016/j.freeradbiomed.2012.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Knowledge of location and intracellular subcompartmentalization is essential for the understanding of redox processes, because oxidants, owing to their reactive nature, must be generated close to the molecules modified in both signaling and damaging processes. Here we discuss known redox characteristics of various mitochondrial microenvironments. Points covered are the locations of mitochondrial oxidant generation, characteristics of antioxidant systems in various mitochondrial compartments, and diffusion characteristics of oxidants in mitochondria. We also review techniques used to measure redox state in mitochondrial subcompartments, antioxidants targeted to mitochondrial subcompartments, and methodological concerns that must be addressed when using these tools. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：2201 / 2208

页数：8

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