Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst

被引：148

作者：

Shin, Jung-Ah ^{[1
]}

Lim, Yeong-Gweon ^{[1
]}

Lee, Kyung-Hee ^{[1
]}

机构：

[1] Agcy Def Dev, Taejon 305600, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 08期

关键词：

BETA-CYCLODEXTRIN; PHARMACEUTICAL APPLICATIONS; 1,3-DIPOLAR CYCLOADDITIONS; HUISGEN CYCLOADDITION; INCLUSION COMPLEXES; TERMINAL ALKYNES; CLICK-CHEMISTRY; TRIAZOLE; IMPROVEMENT; LIGATION;

D O I：

10.1021/jo3000095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H2O in the presence of catalytic amount of beta-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in good to high yields starting from an alkyl bromide, sodium azide, and terminal alkyne.

引用

页码：4117 / 4122

页数：6

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