Cytoreductive Surgery (CRS) Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Platinum-Sensitive Recurrence Epithelial Ovarian Cancer With HRR Mutation: A Phase III Randomized Clinical Trial
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作者:
Qi, Yuwen
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Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Qi, Yuwen
[1
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Zhang, Yaxing
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Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Zhang, Yaxing
[1
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]
Shi, Yuying
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机构:
Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Shi, Yuying
[1
,2
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]
Yao, Shijie
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Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Yao, Shijie
[1
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Dai, Mengyuan
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机构:
Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Dai, Mengyuan
[1
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,3
]
Cai, Hongbing
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机构:
Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
Hubei Canc Clin Study Ctr, Wuhan, Peoples R ChinaWuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
Cai, Hongbing
[1
,2
,3
]
机构:
[1] Wuhan Univ, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
[2] Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China
[3] Hubei Canc Clin Study Ctr, Wuhan, Peoples R China
Background: Epithelial ovarian cancer (EOC) remains the leading cause of gynecologic cancer death worldwide due to the high recurrence rate. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an alternative modality for platinum-sensitive recurrent EOC. The latest studies demonstrate homologous recombination-related (HRR) mutation status increases the sensitivity to platinum-based chemotherapy drugs in EOC. However, the molecular analysis of recurrent EOC patient benefits from HIPEC is unknown. Thus, we aimed to evaluate the efficacy and safety of CRS combined with HIPEC for platinum-sensitive in recurrent EOC with HRR mutation. Methods: This is a phase III randomized controlled clinical trial in patients with platinum-sensitive recurrent EOC. Participants were divided into 2 groups based on the HRR mutation status and randomized to receive CRS + HIPEC. The patients then received periodic chemotherapy and follow-up. Results: The primary objective of this study was to evaluate the effect of CRS + HIPEC compared to CRS alone in patients with a platinum-sensitive recurrent EOC stratified for HRD status. We hypothesize that the addition of HIPEC to CRS improves the progression-free survival (PFS) of platinum-sensitive recurrent EOC patients with HRR mutation compared with patients without HRR mutation. Conclusion: Recurrent EOC has a poor prognosis due to implantation and metastasis in the abdominal cavity. Intraperitoneal chemotherapy reduced seeding by removing free tumor cells. HIPEC utilizes physical and biological properties to significantly increase the clearance rate of tumors. Van Driel WJ et al proposed that HIPEC using platinum-based chemotherapy improves the survival of patients with ovarian cancer. HRR mutation, as a common pathogenic mutation in ovarian cancer, has a predictive effect on the platinum sensitivity of ovarian cancer patients. Whether lobaplatin-based HIPEC will play a greater role in ovarian cancer patients with HRR mutations is currently unknown.
机构:
Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Carioli, G.
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Bertuccio, P.
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Univ Milan, Dept Biomed & Clin Sci, Milan, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Bertuccio, P.
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Boffetta, P.
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Levi, F.
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Univ Lausanne, Inst Social & Prevent Med IUMSP, Unisante, Lausanne, SwitzerlandUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Levi, F.
;
La Vecchia, C.
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Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
La Vecchia, C.
;
Negri, E.
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Univ Milan, Dept Biomed & Clin Sci, Milan, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Negri, E.
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Malvezzi, M.
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Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
机构:
City Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USACity Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA
Dellinger, Thanh H.
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Han, Ernest S.
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City Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USACity Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA
机构:
Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Carioli, G.
;
Bertuccio, P.
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机构:
Univ Milan, Dept Biomed & Clin Sci, Milan, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Bertuccio, P.
;
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机构:
Boffetta, P.
;
Levi, F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lausanne, Inst Social & Prevent Med IUMSP, Unisante, Lausanne, SwitzerlandUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Levi, F.
;
La Vecchia, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
La Vecchia, C.
;
Negri, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Dept Biomed & Clin Sci, Milan, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
Negri, E.
;
Malvezzi, M.
论文数: 0引用数: 0
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机构:
Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, ItalyUniv Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, Milan 20122, Italy
机构:
City Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USACity Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA
Dellinger, Thanh H.
;
Han, Ernest S.
论文数: 0引用数: 0
h-index: 0
机构:
City Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USACity Hope Comprehens Canc Ctr, Div Gynecol Oncol, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA