Synthetic redesign of plant lipid metabolism

被引：75

作者：

Haslam, Richard P. ^{[1
]}

Sayanova, Olga ^{[1
]}

Kim, Hae Jin ^{[2
,3
]}

Cahoon, Edgar B. ^{[2
,3
]}

Napier, Johnathan A. ^{[1
]}

机构：

[1] Rothamsted Res, Biol Chem & Crop Protect, Harpenden AL5 2JQ, Herts, England

[2] Univ Nebraska Lincoln, Ctr Plant Sci Innovat, Lincoln, NE 68588 USA

[3] Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA

来源：

PLANT JOURNAL | 2016年 / 87卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 美国国家科学基金会;

关键词：

fatty acid metabolism; metabolic engineering; plant biotechnology; predictive manipulation; oil crops; POLYUNSATURATED FATTY-ACIDS; CARRIER PROTEIN DESATURASE; CROP CAMELINA-SATIVA; DIACYLGLYCEROL ACYLTRANSFERASE; SUBSTRATE-SPECIFICITY; ALTERNATIVE PATHWAY; REDUCED-VISCOSITY; TRANSGENIC PLANTS; FIELD PRODUCTION; OILSEED CROPS;

D O I：

10.1111/tpj.13172

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired traits in a non-native host is considered. The advantages of a particular oilseed crop, Camelina sativa, as a flexible and utilitarian chassis for advanced metabolic engineering and applied synthetic biology are considered, as are the issues that still represent gaps in our ability to predictably alter plant lipid biosynthesis. Opportunities to deliver useful bio-based products via transgenic plants are described, some of which represent the most complex genetic engineering in plants to date. Future prospects are considered, with a focus on the desire to transition to more (computationally) directed manipulations of metabolism.

引用

页码：76 / 86

页数：11

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