The gene expressions of DNA methylation/demethylation enzymes and cytochrome c oxidase subunit 4 in skeletal muscle of thyroidectomized rats

被引：0

作者：

Peng, Shuhong ^{[2
]}

Xu, Ningying ^{[2
]}

Huang, Liping

Gao, Xiaoheng ^{[1
]}

Zhu, Weifeng ^{[1
]}

Yu, Riyue

Liu, Hongning ^{[1
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China

[2] Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Zhejiang, Peoples R China

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2011年 / 10卷 / 05期

关键词：

Gene expression; Dnmts; Mbd4; Gadd45; alpha; Cox4; THYROID-HORMONE; DE-NOVO; METHYLATION PATTERNS; DEMETHYLATION; METHYLTRANSFERASES; HYPOTHYROIDISM; MAINTENANCE; CHROMOSOME; DNMT3A; FAMILY;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A decrease in mRNA levels for cytochrome c oxidase (COX) subunits was observed in skeletal muscle of hypothyroid rats. However, the precise expression mechanisms of the related genes in hypothyroid state still remain unclear. This study investigated gene expressions of DNA methyltransferases (Dnmts), DNA demethylases and Cox4 in skeletal muscle of thyroidectomized rats. The findings showed that, the mRNA levels of genes encoding Dnmts and DNA demethylases were up-regulated while the mRNA levels of Cox4 down-regulated. These results imply that, DNA methylation might down-regulate Cox4 expression and induce a compensatory mechanism for avoiding an excessive incorporation of 5-C-m into DNA.

引用

页码：730 / 733

页数：4

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