Red Blood Cell Population Dynamics

被引：67

作者：

Higgins, John M. ^{[1
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机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2015年 / 35卷 / 01期

关键词：

Red blood cell population dynamics; Single-RBC measurements; Mathematical modeling; RBC life span; RBC turnover; Diagnostic applications; Predictive medicine; Personalized medicine; RETICULOCYTE; VESICULATION; ERYTHROCYTES; SURVIVAL; ANEMIA; VOLUME;

D O I：

10.1016/j.cll.2014.10.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hematology analyzers provide a static snapshot of the circulating population of red blood cells (RBCs). The RBC population is rapidly changing, with more than 2 million RBCs turning over every second in the typical healthy adult. The static snapshot provided by the complete blood count does not capture many of the dynamic aspects of this population, such as the rate of RBC maturation and the rate of RBC turnover. By integrating basic science with hematology analyzer measurements, it is possible to estimate the rates of these dynamic processes, yielding new insights into human physiology, with potential diagnostic application.

引用

页码：43 / +

页数：16

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