Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs

被引：98

作者：

Schroeter, Hagen ^{[1
,2
]}

Heiss, Christian ^{[3
]}

Spencer, Jeremy P. E. ^{[4
]}

Keen, Carl L. ^{[1
]}

Lupton, Joanne R. ^{[5
]}

Schmitz, Harold H. ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[2] Mars Inc, Mclean, VA USA

[3] Univ Dusseldorf, Dept Cardiol Pulmonol & Vasc Med, Dusseldorf, Germany

[4] Univ Reading, Sch Chem Food & Pharm, Dept Food & Nutr Sci, Reading, Berks, England

[5] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2010年 / 31卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Proanthocyanidins; Epicatechin; Cardiovascular disease; Phytonutrient; Diet; Nutrition; Tea; Cocoa; BLOOD-PRESSURE; RICH COCOA; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; DEPENDENT VASODILATION; VASCULAR FUNCTION; ALPHA-TOCOPHEROL; INFANT LEUKEMIA; DARK CHOCOLATE; HUMAN PLASMA;

D O I：

10.1016/j.mam.2010.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Data on the potential health benefits of dietary flavanols and procyanidins, especially in the context of cardiovascular health, are considerable and continue to accumulate. Significant progress has been made in flavanol analytics and the creation of phytonutrient-content food databases, and novel data emanated from epidemiological investigations as well as dietary intervention studies. However, a comprehensive understanding of the pharmacological properties of flavanols and procyanidins, including their precise mechanisms of action in vivo, and a conclusive, consensus-based accreditation of a causal relationship between intake and health benefits in the context of primary and secondary cardiovascular disease prevention is still outstanding. Thus, the objective of this review is to identify and discuss key questions and gaps that will need to be addressed in order to conclusively demonstrate whether or not dietary flavanols and procyanidins have a role in preventing, delaying the onset of, or treating cardiovascular diseases, and thus improving human life expectancy and quality of life. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：546 / 557

页数：12

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