Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

被引:11
作者
Rufino, Ana T. [1 ]
Ramalho, Ana [1 ]
Sousa, Adelaide [1 ]
de Oliveira, Jose Miguel P. Ferreira [1 ]
Freitas, Paulo [2 ]
Gomez, Manuel A. Gonzalez [3 ]
Pineiro-Redondo, Yolanda [3 ]
Rivas, Jose [3 ]
Carvalho, Felix [4 ]
Fernandes, Eduarda [1 ]
Freitas, Marisa [1 ]
机构
[1] Univ Porto, LAQV, REQUIMTE, Lab Appl Chem,Dept Chem Sci,Fac Pharm, P-4050313 Porto, Portugal
[2] Int Iberian Nanotechnol Lab, P-4715330 Braga, Portugal
[3] Univ Santiago de Compostela, Dept Appl Phys, Nanotechnol & Magnetism Lab NANOMAG, Santiago De Compostela 15782, Spain
[4] Univ Porto, UCIBIO, REQUIMTE, Lab Toxicol,Dept Biol Sci,Fac Pharm, P-4050313 Porto, Portugal
来源
MOLECULES | 2021年 / 26卷 / 21期
关键词
inflammation; nanoparticles; intestinal cells; neutrophils; flavonoids; IN-VITRO; ENGINEERED NANOPARTICLES; CHLORINATED FLAVONOIDS; CACO-2; TOXICITY; CYTOTOXICITY; INHIBITION; QUERCETIN; CELLS;
D O I
10.3390/molecules26216610
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.</p>
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页数:19
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