Ultrasound-guided Percutaneous ethanol injection Protocol to Treat solid and Mixed Thyroid nodules

被引：10

作者：

Felicio, Joao Soares ^{[1
]}

Silva Conceicao, Antonio Maria ^{[1
]}

Santos, Flavia Marques ^{[1
]}

Minami Sato, Michelle Masuyo ^{[1
]}

Bastos, Fabiola de Arruda ^{[1
]}

Contente Braga de Souza, Ana Carolina ^{[1
]}

Koury, Camila Cavalcante ^{[1
]}

Abrahao Neto, Joao Felicio ^{[1
]}

Cunha de Melo, Franciane Trindade ^{[1
]}

Carvalho, Carolina Tavares ^{[1
]}

Arbage, Thais Pontes ^{[1
]}

de Figueiredo Junior, Antonio Bentes ^{[1
]}

de Rider Brito, Hana Andrade ^{[1
]}

Mourao Junior, Marcelo Oliveira ^{[1
]}

Resende, Fabricio de Souza ^{[1
]}

Peixoto, Amanda Soares ^{[1
]}

Felicio, Karem Mileo ^{[1
]}

机构：

[1] Fed Univ Para, Univ Hosp Joao de Barros Barreto, Div Endocrinol, BR-66059 Belem, Para, Brazil

来源：

FRONTIERS IN ENDOCRINOLOGY | 2016年 / 7卷

关键词：

thyroid nodules; percutaneous ethanol injection; alcoholization; US-guided; nodule volume reduction; 5-YEAR FOLLOW-UP; LONG-TERM; RANDOMIZED-TRIAL; CYSTIC NODULES; ABLATION; MANAGEMENT; THERAPY; EFFICACY; DISEASE; COLD;

D O I：

10.3389/fendo.2016.00052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: Ultrasound (US)-guided percutaneous ethanol injection (PEI) has been proposed for treatment of benign thyroid nodules (TNs). However, there is no consensus for the optimal amount of ethanol injection, number of applications, and time to re-evaluation in order to achieve maximum volume reduction with minimum adverse effects. Objective: The purpose of the present study was to analyze the effectiveness of an US -guided PEI protocol to treat solid and mixed TNs based on a new target outcome. Patients and methods: We performed a prospective study evaluating the results of PEI in 52 patients with benign solid and mixed TNs. The ethanol dose was fixed in 30% of the nodular volume per session. Patients returned 1 month after each session for US re-evaluation. Therapeutic success was defined as volume reduction of at least 30% associated with disappearance of clinical symptoms and a complete esthetic satisfaction reported by the patient. Results: We performed a mean of 2.8 +/- 1.9 PEI sessions, with an average total volume of ethanol injected of 9.1 +/- 10.3 ml, and a follow-up time of 10.0 +/- 8.7 months. There was a reduction of at least 50% of the initial nodular volume in 33 patients (63.5%). In 11 patients (21.2%), the reduction did not reach 50% (mean reduction of 31 +/- 11 %), but 6 of them reported esthetically satisfactory results and treatment was stopped. Our therapeutic success rate considering the patients with esthetic improvement was 75%. There were no severe complications. Conclusion: Our protocol is effective and safe to treat solid and mixed benign TNs based on our established outcome.

引用

页数：6

共 62 条

[1] COMPARISON BETWEEN ETHANOL SCLEROTHERAPY AND EMPTYING WITH INJECTION OF SALINE IN TREATMENT OF THYROID CYSTS [J].