A Review on Bioactive Compounds from Marine-Derived Chaetomium Species

被引：17

作者：

Tian, Yuan ^{[1
]}

Li, Yanling ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Coll Life Sci, Tai An 271016, Shandong, Peoples R China

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2022年 / 32卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Chaetomium; secondary metabolite; structural diversity; biological activity; CYTOTOXIC METABOLITES; ENDOPHYTIC FUNGUS; ABSOLUTE STEREOSTRUCTURES; AZAPHILONES; CHAETOMUGILINS; NEOECHINULIN; GLOBOSUM; CYTOCHALASINS; CHEMISTRY; APOPTOSIS;

D O I：

10.4014/jmb.2201.01007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Filamentous marine fungi have proven to be a plentiful source of new natural products. Chaetomium, a widely distributed fungal genus in the marine environment, has gained much interest within the scientific community. In the last 20 years, many potential secondary metabolites have been detected from marine-derived Chaetomium. In this review, we attempt to provide a comprehensive summary of the natural products produced by marine-derived Chaetomium species. A total of 122 secondary metabolites that were described from 2001 to 2021 are covered. The structural diversity of the compounds, along with details of the sources and relevant biological properties are also provided, while the relationships between structures and their bioactivities are discussed. It is our expectation that this review will be of benefit to drug development and innovation.

引用

页码：541 / 550

页数：10

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