Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography mass spectrometry

被引：0
|
作者：
Mester, Z
Horváth, G
Vitányi, G
Lelik, L
Fodor, P
机构：
[1] Univ Hort & Food Ind, Dept Chem & Biochem, H-1114 Budapest, Hungary
[2] Inst Drug Res Ltd, Budapest, Hungary
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1999年 / 13卷 / 05期
关键词：
D O I：
10.1002/(SICI)1097-0231(19990315)13:5<350::AID-RCM490>3.0.CO;2-V
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm(-3) respectively. This simple and rapid method has good precision and accuracy. Fragmentation routes of derivatized MMA and DMA are suggested on accurate mass measurements. Copyright (C) 1999 John Wiley & Sons, Ltd.
引用
收藏
页码：350 / 353
页数：4
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