Tubal flushing with oil-based or water-based contrast at hysterosalpingography for infertility: long-term reproductive outcomes of a randomized trial

被引：25

作者：

van Rijswijk, Joukje ^{[1
]}

van Welie, Nienke ^{[1
]}

Dreyer, Kim ^{[1
]}

Pham, Clarabelle T. ^{[2
]}

Verhoeve, Harold R. ^{[3
]}

Hoek, Annemieke ^{[4
]}

de Bruin, Jan Peter ^{[5
]}

Nap, Annemiek W. ^{[6
]}

van Hooff, Machiel H. A. ^{[7
]}

Goddijn, Mariette ^{[8
]}

Hooker, Angelo B. ^{[9
]}

Bourdrez, Petra ^{[10
]}

van Dongen, Angelique J. C. M. ^{[11
]}

van Rooij, Ilse A. J. ^{[12
]}

van Rijnsaardt-Lukassen, Henrike G. M. ^{[13
]}

van Golde, Ron J. T. ^{[14
]}

van Heteren, Cathelijne F. ^{[15
]}

Pelinck, Marie J. ^{[16
]}

Duijn, Annette E. J. ^{[17
]}

Kaplan, Mesrure ^{[18
]}

Lambalk, Cornelis B. ^{[1
]}

Mijatovic, Velja ^{[1
]}

Mol, Ben W. J. ^{[19
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC, Dept Reprod Med, Boelelaan 1118, NL-1081 HV Amsterdam, Netherlands

[2] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Vic, Australia

[3] Onze Lieve Vrouw Hosp, Dept Obstet & Gynaecol, Amsterdam, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Reprod Med & Gynaecol, Hanzeplein, Netherlands

[5] Jeroen Bosch Hosp, Dept Obstet & Gynaecol, sHertogenbosch, Netherlands

[6] Rijnstate Hosp, Dept Obstet & Gynaecol, Arnhem, Netherlands

[7] Franciscus Hosp, Dept Obstet & Gynaecol, Rotterdam, Netherlands

[8] Vrije Univ Amsterdam, Amsterdam UMC, Ctr Reprod Med, Amsterdam, Netherlands

[9] Zaans Med Ctr, Dept Obstet & Gynaecol, Zaandam, Netherlands

[10] VieCuri Med Ctr, Dept Obstet & Gynaecol, Venlo, Netherlands

[11] Hosp Gelderse Vallei, Dept Obstet & Gynaecol, Ede, Netherlands

[12] Elisabeth TweeSteden Hosp, Dept Obstet & Gynaecol, Tilburg, Netherlands

[13] Albert Schweitzer Hosp, Dept Obstet & Gynaecol, Dordrecht, Netherlands

[14] Maastricht UMC, Dept Obstet & Gynaecol, Maastricht, Netherlands

[15] Canisius Wilhelmina Hosp, Dept Obstet & Gynaecol, Nijmegen, Netherlands

[16] Scheper Hosp, Dept Obstet & Gynaecol, Emmen, Netherlands

[17] Vrouwenkliniek Zuidoost, Amsterdam, Netherlands

[18] Ropcke Zweers Hosp, Hardenberg, Netherlands

[19] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia

来源：

FERTILITY AND STERILITY | 2020年 / 114卷 / 01期

关键词：

Female infertility; hysterosalpingography; oil-based contrast medium; water-based contrast medium; ongoing pregnancy; MEDIA;

D O I：

10.1016/j.fertnstert.2020.03.022

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the impact of oil -based versus water -based contrast on pregnancy and live birth rates < 5 years after hysterosalpingography (HSG) in infertile women. Design: A 5 -year follow-up study of a multicenter randomized trial. Setting: Hospitals. Patient(s): Infertile women with an ovulatory cycle, 18 - 39 years of age, and having a low risk of tubal pathology. Intervention(s): Use of oil -based versus water -based contrast during HSG. Main Outcome Measure(s): Ongoing pregnancy, live births, time to ongoing pregnancy, second ongoing pregnancy. Result(s): A total of 1,119 women were randomly assigned to HSG with oil -based contrast (n = 557) or water -based contrast (n = 562). After 5 years, 444 of 555 women in the oil group (80.0%) and 419 of 559 women in the water group (75.0%) had an ongoing pregnancy (relative risk [RR] 1.07; 95% con fi dence interval [CI] 1.00 - 1.14), and 415 of 555 women in the oil group (74.8%) and 376 of 559 women in the water group (67.3%) had live births (RR 1.11; 95% CI 1.03 - 1.20). In the oil group, 228 pregnancies (41.1%) were conceived naturally versus 194 (34.7%) pregnancies in the water group (RR 1.18; 95% CI 1.02 - 1.38). The time to ongoing pregnancy was signi fi cantly shorter in the oil group versus the water group (10.0 vs. 13.7 months; hazard ratio, 1.25; 95% CI 1.09 - 1.43). No difference was found in the occurrence of a second ongoing pregnancy. Conclusion(s): During a 5 -year time frame, ongoing pregnancy and live birth rates are higher after tubal fl ushing with oil -based contrast during HSG compared with water -based contrast. More pregnancies are naturally conceived and time to ongoing pregnancy is shorter after HSG with oil -based contrast. Clinical Trial Registration Number: Netherlands Trial Register (NTR) 3270 and NTR6577(www.trialregister.nl). (Fertil Steril (R) 2020;114:155-62. (C) 2020 by American Society for Reproductive Medicine.)

引用

页码：155 / 162

页数：8

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