When Should F-18 FDG PET/CT Be Used Instead of 68Ga-DOTA-Peptides to Investigate Metastatic Neuroendocrine Tumors?

被引：5

作者：

Fuccio, Chiara ^{[4
]}

Musto, Alessandra ^{[2
,3
]}

Cambioli, Silvia ^{[4
]}

Castellucci, Paolo ^{[4
]}

Pantaleo, Maria A. ^{[5
]}

Nanni, Cristina ^{[4
]}

Montini, Gian C. ^{[4
]}

Campana, Davide ^{[6
]}

Tomassetti, Paolo ^{[6
]}

Bellan, Elena ^{[2
,3
]}

Massaro, Arianna ^{[2
,3
]}

Grassetto, Gaia ^{[2
,3
]}

Rubello, Domenico ^{[1
,2
,3
]}

Fanti, Stefano ^{[4
]}

机构：

[1] Santa Maria della Misericordia Hosp, Dept Nucl Med, PET Ctr, I-45100 Rovigo, Italy

[2] Santa Maria della Misericordia Hosp, Dept Med Phys, I-45100 Rovigo, Italy

[3] Santa Maria della Misericordia Hosp, Dept Radiol, I-45100 Rovigo, Italy

[4] S Orsola Malpighi Univ Hosp, Azienda Osped Univ Bologna, Dept Nucl Med, Bologna, Italy

[5] S Orsola Malpighi Univ Hosp, Azienda Osped Univ Bologna, Dept Oncol, Bologna, Italy

[6] S Orsola Malpighi Univ Hosp, Azienda Osped Univ Bologna, Dept Internal Med, Bologna, Italy

来源：

CLINICAL NUCLEAR MEDICINE | 2011年 / 36卷 / 12期

关键词：

aggressive NETs; PET/CT; F-18; FDG; Ga-68-DOTA-NOC; management; POSITRON-EMISSION-TOMOGRAPHY; Y-90-DOTATOC THERAPY; PHARMACOKINETICS; GA-68-DOTATOC;

D O I：

10.1097/RLU.0b013e31823361f7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 67-year-old man, previously operated for a pancreatic neuroendocrine tumor (NET), had progressive increase of serum chromogranin A during follow-up. Sequential Ga-68-DOTA-NOC and F-18 FDG PET/CT were performed. Ga-68-DOTA-NOC imaging was negative, whereas F-18 FDG PET/CT showed 2 hypermetabolic hepatic lesions demonstrated at CT-guided biopsy as metastatic deposits from a high-grade (G3) aggressive NET. Despite the large consensus of SPECT or PET with radiolabeled somatostatin analogs as first choice in functional imaging for detecting NETs metastasis, F-18 FDG may occasionally be the right tracer to provide accurate diagnostic and prognostic information in aggressive G3 NET.

引用

页码：1109 / 1111

页数：3

共 8 条

[1]

Adams S, 1998, EUR J NUCL MED, V25, P79

[2] 68Ga-DOTANOC PET/CT Clinical Impact in Patients with Neuroendocrine Tumors [J].

Ambrosini, Valentina ;

Campana, Davide ;

Bodei, Lisa ;

Nanni, Cristina ;

Castellucci, Paolo ;

Allegri, Vincenzo ;

Montini, Gian Carlo ;

Tomassetti, Paola ;

Paganelli, Giovanni ;

Fanti, Stefano .

JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (05) :669-673

[3] Functional Imaging of neuroendocrine tumors with combined PET/CT using 68Ga-DOTATATE (Dota-DPhe1,Tyr3-octreotate) and 18F-FDG [J].

Kayani, Irfan ;

Bomanji, Jamshed B. ;

Groves, Ashley ;

Conway, Gerard ;

Gacinovic, Sveto ;

Win, Thida ;

Dickson, John ;

Caplin, Martyn ;

Ell, Peter Joseph .

CANCER, 2008, 112 (11) :2447-2455

[4] Evaluation of the pharmacokinetics of 68Ga-DOTATOC in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy [J].

Koukouraki, S ;

Strauss, LG ;

Georgoulias, V ;

Schuhmacher, J ;

Haberkorn, U ;

Karkavitsas, N ;

Dimitrakopoulou-Strauss, A .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2006, 33 (04) :460-466

[5] Comparison of the pharmacokinetics of 68Ga-DOTATOC and [18F]FDG in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy [J].

Koukouraki, Sophia ;

Strauss, Ludwig G. ;

Georgoulias, Vassilios ;

Eisenhut, Michael ;

Haberkorn, Uwe ;

Dimitrakopoulou-Strauss, Antonia .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2006, 33 (10) :1115-1122

[6]

Krenning EP, 2005, J NUCL MED, V46, p76S

[7] Neuroendocrine tumor imaging:: Can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior? [J].

Pasquali, C ;

Rubello, D ;

Sperti, C ;

Gasparoni, P ;

Liessi, G ;

Chierichetti, F ;

Ferlin, G ;

Pedrazzoli, S .

WORLD JOURNAL OF SURGERY, 1998, 22 (06) :588-592

[8] Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours [J].

Ramage, JK ;

Davies, AHG ;

Ardill, J ;

Bax, N ;

Caplin, M ;

Grossman, A ;

Hawkins, R ;

McNicol, AM ;

Reed, N ;

Sutton, R ;

Thakker, R ;

Aylwin, S ;

Breen, D ;

Britton, K ;

Buchanan, K ;

Corrie, P ;

Gillams, A ;

Lewington, V ;

McCance, D ;

Meeran, K ;

Watkinson, A .

GUT, 2005, 54 :iv1-iv16

← 1 →