A Biomimetic Approach to Lanthionines

被引：21

作者：

Aydillo, Carlos ^{[1
]}

Avenoza, Alberto ^{[1
]}

Busto, Jesus H. ^{[1
]}

Jimenez-Oses, Gonzalo ^{[1
]}

Peregrina, Jesus M. ^{[1
]}

Zurbano, Maria M. ^{[1
]}

机构：

[1] Univ La Rioja, Ctr Invest Sintesis Quim, Dept Quim, UA CSIC, E-26006 Logrono, Spain

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

ORTHOGONALLY PROTECTED LANTHIONINES; ASYMMETRIC-SYNTHESIS; SOLID-PHASE; AMINO-ACIDS; CONJUGATE ADDITION; MICHAEL ADDITION; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL-ACTIVITIES; STEREOISOMERS; PEPTIDES;

D O I：

10.1021/ol203068s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric sulfa-Michael additions of appropriately protected L- and D-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and beta-methyllanthionine (Me Lan), which are unusual bis-alpha-amino acids found in the emerging lantibiotics such as nisin.

引用

页码：334 / 337

页数：4

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