Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome

被引：24
|
作者：
Gu, Qiao-Yan [1 ,2 ]
Zhang, Jun [1 ]
Feng, Yi-Chao [2 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 2, Xian, Shaanxi Provinc, Peoples R China
[2] Yanan Univ, Dept Gastroenterol, Affiliated Hosp, Yanan, Shaanxi Provinc, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期
关键词：
Bifidobacterium longum; inflammasome; NLRP3; postinfectious irritable bowel syndrome; INTESTINAL BACTERIAL OVERGROWTH; FECAL MICROBIOTA; MODEL; LACTOBACILLUS;
D O I：
10.3109/21691401.2015.1111238
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n=10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Significantly more IL-18 and IL-1 were expressed in PI-2W and PI-8W groups than those in normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1 expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.
引用
收藏
页码：1933 / 1937
页数：5
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