Prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in Okinawa, southern Japan

被引:47
作者
Deng, Zeyi [1 ]
Hasegawa, Masahiro [1 ]
Matayoshi, Sen [1 ]
Kiyuna, Asanori [1 ]
Yamashita, Yukashi [1 ]
Maeda, Hiroyuki [1 ]
Suzuki, Mikio [1 ]
机构
[1] Univ Ryukyus, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Nishihara, Okinawa 9030215, Japan
基金
日本学术振兴会;
关键词
Human papilloma virus; Head and neck squamous cell carcinoma; Oropharynx; Oral cavity; Okinawa; OROPHARYNGEAL CANCER; VIRUS; DNA; HUMAN-PAPILLOMAVIRUS-16; INFECTION; RISK;
D O I
10.1007/s00405-011-1515-0
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Previous studies from Okinawa, a subtropical island in southern Japan, demonstrated a higher prevalence of human papillomavirus (HPV) in oral carcinoma and a higher incidence of oral and pharyngeal carcinoma than those for mainland Japan. The present study aims to investigate epidemiologic and clinical features of HPV in head and neck squamous cell carcinoma (HNSCC) in Okinawa. A total of 150 DNA samples from 150 Okinawan patients with head and neck squamous cell carcinoma (HNSCC) were screened for HPV sequences by PCR using three consensus primer sets, and HPV types were determined by direct sequencing. The samples were consisted of 46 cases from the hypopharynx, 44 from the oropharynx, 16 from the larynx, 25 from the oral cavity, 10 from the maxillary sinus, and 9 from the nasopharynx. HPV DNA was detected in 45 (30.0%) HNSCCs, and HPV-16 was identified in 86.7% of positive specimens. The highest prevalence of the HPV sequence was found in oropharyngeal carcinomas (50.0%), especially in tonsillar cancer (63.6%). Multivariate analysis showed that oropharyngeal carcinoma (P = 0.002; OR = 5.34; 95% CI = 1.83-15.58), oral cavity carcinoma (P = 0.012; OR = 4.94; 95% CI = 1.43-17.10), and histological poor differentiation (P = 0.011; OR = 4.25; 95% CI = 1.39-13.04) each independently increased the prevalence of HPV infection. The present study reveals that patients with HNSCC, e.g., oropharyngeal and oral cavity carcinomas, in Okinawa have relatively high HPV-16 positive rates and low HPV-18 positive rates comparing with mainland Japan.
引用
收藏
页码:1625 / 1631
页数:7
相关论文
共 22 条
[1]  
[Anonymous], J GEN VIROL
[2]  
[Anonymous], 2005, World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours
[3]   Presence of DNA of human papillomavirus 16 but no other types in tumor-free tonsillar tissue [J].
Chen, RW ;
Sehr, P ;
Waterboer, T ;
Leivo, I ;
Pawlita, M ;
Vaheri, A ;
Aaltonen, LM .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (03) :1408-1410
[4]   Case-control study of human papillomavirus and oropharyngeal cancer [J].
D'Souza, Gypsyamber ;
Kreimer, Aimee R. ;
Viscidi, Raphael ;
Pawlita, Michael ;
Fakhry, Carole ;
Koch, Wayne M. ;
Westra, William H. ;
Gillison, Maura L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (19) :1944-1956
[5]   Rising incidence of oropharyngeal cancer and the role of oncogenic human Papilloma virus [J].
Ernster, Joel A. ;
Sciotto, Cosimo G. ;
O'Brien, Maureen M. ;
Finch, Jack L. ;
Robinson, Linda J. ;
Willson, Thomas ;
Mathews, Michael .
LARYNGOSCOPE, 2007, 117 (12) :2115-2128
[6]   Evidence for a causal association between human papillomavirus and a subset of head and neck cancers [J].
Gillison, ML ;
Koch, WM ;
Capone, RB ;
Spafford, M ;
Westra, WH ;
Wu, L ;
Zahurak, ML ;
Daniel, RW ;
Viglione, M ;
Symer, DE ;
Shah, KV ;
Sidransky, D .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (09) :709-720
[7]   Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium [J].
Hashibe, Mia ;
Brennan, Paul ;
Chuang, Shu-Chun ;
Boccia, Stefania ;
Castellsague, Xavier ;
Chen, Chu ;
Curado, Maria Paula ;
Dal Maso, Luigino ;
Daudt, Alexander W. ;
Fabianova, Eleonora ;
Fernandez, Leticia ;
Wuensch-Filho, Victor ;
Franceschi, Silvia ;
Hayes, Richard B. ;
Herrero, Rolando ;
Kelsey, Karl ;
Koifman, Sergio ;
La Vecchia, Carlo ;
Lazarus, Philip ;
Levi, Fabio ;
Lence, Juan J. ;
Mates, Dana ;
Matos, Elena ;
Menezes, Ana ;
McClean, Michael D. ;
Muscat, Joshua ;
Eluf-Neto, Jose ;
Olshan, Andrew F. ;
Purdue, Mark ;
Rudnai, Peter ;
Schwartz, Stephen M. ;
Smith, Elaine ;
Sturgis, Erich M. ;
Szeszenia-Dabrowska, Neonilia ;
Talamini, Renato ;
Wei, Qingyi ;
Winn, Deborah M. ;
Shangina, Oxana ;
Pilarska, Agnieszka ;
Zhang, Zuo-Feng ;
Ferro, Gilles ;
Berthiller, Julien ;
Boffetta, Paolo .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (02) :541-550
[8]   Human papillomaviruses in head and neck cancer:: 8 year-survival-analysis of 73 patients [J].
Hoffmann, M ;
Görögh, T ;
Gottschlich, S ;
Lohrey, C ;
Rittgen, W ;
Ambrosch, P ;
Schwarz, E ;
Kahn, T .
CANCER LETTERS, 2005, 218 (02) :199-206
[9]  
Klussmann JP, 2001, CANCER-AM CANCER SOC, V92, P2875, DOI 10.1002/1097-0142(20011201)92:11<2875::AID-CNCR10130>3.0.CO
[10]  
2-7