Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402

被引：44

作者：

Yang, HL ^{[1
]}

机构：

[1] Wenzhou Univ, Sch Life & Environm Sci, Wenzhou 325000, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 12期

关键词：

cell cycle; cytotoxicity; Ganoderma lucidum; hepatoma; submerged culture;

D O I：

10.1007/s10529-005-6191-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ganoderic acid (GA), produced by submerged culture of Ganoderma lucidum, at 500 mu g/ml, caused nearly a 70% inhibition of the growth of human hepatoma cell line BEL7402 but not of a normal human liver cell line L02. Flow cytometry analyses showed that GA blocked the BEL7402 cell cycle at the transition from G(1) to S phase.

引用

页码：835 / 838

页数：4

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