Synthesis of new pH-sensitive amphiphilic block copolymers and study for the micellization using a fluorescence probe

被引：14

作者：

Kim, Kyung Min ^{[1
]}

Choi, Song-Yee ^{[1
]}

Jeon, Hee Jeong ^{[1
]}

Lee, Jae Yeol ^{[1
]}

Choo, Dong Joon ^{[1
]}

Kim, Jungahn ^{[1
]}

Kang, Yong Soo ^{[2
]}

Yoo, Hyun-Oh ^{[2
]}

机构：

[1] Kyung Hee Univ, Dept Chem, Seoul 130701, South Korea

[2] Hanyang Univ, Dept Chem Engn, Seoul 133791, South Korea

来源：

MACROMOLECULAR RESEARCH | 2008年 / 16卷 / 02期

关键词：

pH-sensitive block copolymer; macroinitiator; atom transfer radical polymerization; sulfonamide groups; micellization; fluorescence probe;

D O I：

10.1007/BF03218847

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This paper reports a facile synthesis of new water-soluble poly(ethylene oxide) (PEO)-based amphiphilic block copolymers showing pH sensitive phase transition behaviors. The copolymers were prepared by atom transfer radical polymerization (ATRP) of methacrylamide type of monomers carrying a sulfonamide group using a PEO-based macroinitiator and a Cu(I)Br/Me6TREN catalytic system in aqueous media. The resulting polymers were characterized by a combination of H-1-NMR, size exclusion chromatography, and UV/Visible spectrophotometeric analysis. The micellization of the block copolymers as a drug-loading mechanism in aqueous media using fluorescein salt was examined as a function of pH. The stable micelle formation and its loading efficacy suggest that the block copolymers can be used as precursors for drug-nanocontainers.

引用

页码：169 / 177

页数：9

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