Study on Drug Resistance Mediated by Expression of HER-2 and LRP in Tumor Tissues of Patients with Gastric Cancer and Expression Correlation Between HER-2 and LRP

被引：0

作者：

Zhou, Pengzhe ^{[1
]}

Yu, Honghai ^{[1
]}

Zhang, Gang ^{[1
]}

Zhang, Jinzhuo ^{[1
]}

Hao, Yingxia ^{[1
]}

机构：

[1] Baoding First Cent Hosp, Dept Gastroenterol, Baoding 071000, Peoples R China

来源：

ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY | 2019年 / 41卷 / 01期

关键词：

drug resistance; gastric cancer; HER-2; human epidermal growth factor receptor 2; immunohistochemical; LRP; lung resistance protein; MULTIDRUG-RESISTANCE; BREAST-CANCER; PROTEIN-1;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

OBJECTIVE: To observe expression of human epidermal growth factor receptor 2 (HER-2) and lung resistance protein (LRP) in tumor tissues of patients with gastric cancer and to explore the relationship between HER-2-mediated gastric cancer resistance and LRP expression. STUDY DESIGN: Immunohistochemical method was applied to test HER-2 and LRP expression in 65 specimens of gastric cancer and 32 non-gastric cancer patients. Western blot was used to examine the phosphorylation state of HER-2 in non-gastric cancer patients and in gastric cancer patients with or without lymphatic metastasis. RESULTS: HER-2 and LRP expression of patients with gastric cancer had no obvious correlation with patient age, gender, tissue differentiation degree, and infiltration depth. The research results showed that HER-2 and LRP expression in gastric cancer tissues presented positive correlation (r=0.335, p <0.05). Phosphorylation of HER-2 was highest in patients with gastric cancer and lymphatic metastasis and higher in patients with gastric cancer only, as compared to that in non-gastric cancer patients. CONCLUSION: LRP may be one of the resistance proteins causing primary resistance of gastric cancer. Activation of HER-2 may mediate gastric cancer resistance through influencing LRP expression.

引用

页码：9 / 15

页数：7

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