Characterization of two vasoactive peptides isolated from the plasma of the snake Crotalus durissus terrificus

被引：5
作者：
Barreto, S. A. [1 ]
Chaguri, L. C. A. G. [1 ]
Prezoto, B. C. [2 ]
Lebrun, I. [1 ]
机构：
[1] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo, Brazil
[2] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo, Brazil
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
Hypotensive; Kinin; Vasoactive; Angiotensin; Peptide; Snakes; Vascular; ANGIOTENSIN-CONVERTING ENZYME; KALLIKREIN-KININ SYSTEM; BRADYKININ-POTENTIATING PEPTIDES; BOTHROPS-JARARACA VENOM; ENDOTHELIAL-CELLS; NITRIC-OXIDE; CARDIOVASCULAR ACTIONS; BIOLOGICAL-ACTIVITY; SUBSTANCE-P; GUINEA-PIG;
D O I：
10.1016/j.biopha.2011.10.001
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Incubation of plasma from the snake Crotalus durissus terrificus (CDTP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for two sequences as: (Ser - Ile - Pro - Gln - Ala - Pro - Thr - Ser - Asn - Leu - Ile - Glu - Ala - Thr - Lys) and (Lys - Pro - Asp - Ala Asn - Gln - Val - Leu - Ile - Gln - Val - Ile - Gly - Val). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. Bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake (CDT) and rats (Wistar); this hypotensive effect was also potentiated by captopril-an angiotensin-converting (0.1 mg/kg) enzyme inhibitor. (C) 2012 Elsevier Masson SAS. All rights reserved.
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收藏
页码：256 / 265
页数：10
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