Immune checkpoint blockade in infectious diseases

被引：399
作者：
Wykes, Michelle N. [1 ]
Lewin, Sharon R. [2 ,3 ,4 ,5 ]
机构：
[1] QIMR Berghofer Med Res Inst, 300 Herston Rd, Brisbane, Qld 4006, Australia
[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3000, Australia
[3] Royal Melbourne Hosp, Melbourne, Vic 3000, Australia
[4] Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3004, Australia
[5] Monash Univ, Melbourne, Vic 3004, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 02期
基金：
英国医学研究理事会;
关键词：
T-CELL EXHAUSTION; PROGRAMMED DEATH-1; PD-1; EXPRESSION; UP-REGULATION; LYMPHOCYTE ATTENUATOR; ACQUIRED-IMMUNITY; B-LYMPHOCYTE; PLASMODIUM-FALCIPARUM; INHIBITORY RECEPTORS; ANTI-PD-L1; ANTIBODY;
D O I：
10.1038/nri.2017.112
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The upregulation of immune checkpoint molecules, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute infections, such as malaria, as well as during chronic persistent viral infections, including HIV and hepatitis B virus. These pathways are important for preventing immune-driven pathology but can also limit immune-mediated clearance of the infection. The recent success of immune checkpoint blockade in cancer therapy suggests that targeting these pathways would also be effective for preventing and treating a range of infectious diseases. Here, we review our current understanding of immune checkpoint pathways in the pathogenesis of infectious diseases and discuss the potential for therapeutically targeting these pathways in this setting.
引用
收藏
页码：91 / 104
页数：14
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