A facile route to pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazoles, novel heterocyclic derivatives

被引：7

作者：

Tereshchenko, AD

Tolmachev, AA

Tverdokhlebov, AV

机构：

[1] Enamine Ltd Co, UA-02042 Kiev, Ukraine

[2] Kiev Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine

来源：

SYNTHESIS-STUTTGART | 2004年 / 03期

关键词：

alkylations; 2-benzimidazoleacetonitrile; heterocycles pyrrolo[3 ',4 ': 3,4]pyrido[1,2-a]benzimidazoles; ring closure;

D O I：

10.1055/s-2004-815950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title system derivatives were prepared in two steps. Thus the condensation of 2-benzimidazoleacetonitrile with ethyl 4-chloro-3-oxobutanoate led to the 3-chloromethyl-1,5-dihydro-1-oxopyrido[1,2-a]benzimidazole-4-carbonitrile. Further amination of the obtained chloronitrile with primary amines yielded 1-amino-2,3-dihydro-2-R-5H-pyrrolo[3',4':3,4]pyrido[1,2-a]benzimidazol- 5-ones.

引用

页码：373 / 376

页数：4

共 43 条

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