A facile route to pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazoles, novel heterocyclic derivatives

被引：7
|
作者：
Tereshchenko, AD
Tolmachev, AA
Tverdokhlebov, AV
机构：
[1] Enamine Ltd Co, UA-02042 Kiev, Ukraine
[2] Kiev Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine
来源：
SYNTHESIS-STUTTGART | 2004年 / 03期
关键词：
alkylations; 2-benzimidazoleacetonitrile; heterocycles pyrrolo[3 ',4 ': 3,4]pyrido[1,2-a]benzimidazoles; ring closure;
D O I：
10.1055/s-2004-815950
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The title system derivatives were prepared in two steps. Thus the condensation of 2-benzimidazoleacetonitrile with ethyl 4-chloro-3-oxobutanoate led to the 3-chloromethyl-1,5-dihydro-1-oxopyrido[1,2-a]benzimidazole-4-carbonitrile. Further amination of the obtained chloronitrile with primary amines yielded 1-amino-2,3-dihydro-2-R-5H-pyrrolo[3',4':3,4]pyrido[1,2-a]benzimidazol- 5-ones.
引用
收藏
页码：373 / 376
页数：4
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