BMP-2-loaded silica nanotube fibrous meshes for bone generation

被引：22

作者：

Chen, Song ^{[1
]}

Shi, Xuetao ^{[2
]}

Morita, Hiromi ^{[3
]}

Li, Jie ^{[3
]}

Ogawa, Nobuhiro ^{[1
]}

Ikoma, Toshiyuki ^{[4
]}

Hayakawa, Satoshi ^{[5
]}

Shirosaki, Yuki ^{[5
]}

Osaka, Akiyoshi ^{[5
]}

Hanagata, Nobutaka ^{[1
,3
]}

机构：

[1] Natl Inst Mat Sci, Biomat Unit, Tsukuba, Ibaraki 3050047, Japan

[2] Tohoku Univ, WPI Adv Inst Mat Res, Aoba Ku, Sendai, Miyagi 9808577, Japan

[3] Natl Inst Mat Sci, Nanotechnol Innovat Stn, Tsukuba, Ibaraki 3050047, Japan

[4] Tokyo Inst Technol, Dept Met & Ceram Sci, Meguro Ku, Tokyo 1528550, Japan

[5] Okayama Univ, Grad Sch Nat Sci & Technol, Kita Ku, Okayama 7008530, Japan

来源：

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | 2011年 / 12卷 / 06期

关键词：

silica nanotube; bone morphological protein-2 (BMP-2); osteoblasts; bone; MORPHOGENETIC PROTEIN-2; MICROSTRUCTURE; NANOPARTICLES; TITANIUM; BMP-2;

D O I：

10.1088/1468-6996/12/6/065003

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

引用

页数：5

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