Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox

被引：33

作者：

Faundez, Mario ^{[1
,3
]}

Lopez-Munoz, Rodrigo ^{[1
]}

Torres, Gloria ^{[1
]}

Morello, Antonio ^{[1
]}

Ferreira, Jorge ^{[1
]}

Kemmerling, Ulrike ^{[2
]}

Orellana, Myriam ^{[1
]}

Maya, Juan D. ^{[1
]}

机构：

[1] Univ Chile, Fac Med, Mol & Clin Pharmacol Program, ICBM, Santiago 7, Chile

[2] Univ Chile, Fac Med, Program Anat & Develop Biol, ICBM, Santiago 7, Chile

[3] Univ Valparaiso, Fac Farm, Valparaiso, Chile

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 05期

关键词：

D O I：

10.1128/AAC.01454-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.

引用

页码：1837 / 1839

页数：3

共 17 条

[1] Ovothiol and trypanothione as antioxidants in trypanosomatids [J].

Ariyanayagam, MR ;

Fairlamb, AH .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 115 (02) :189-198

[2] INHIBITION OF GLUTATHIONE SYNTHESIS AS A CHEMOTHERAPEUTIC STRATEGY FOR TRYPANOSOMIASIS [J].

ARRICK, BA ;

GRIFFITH, OW ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 153 (03) :720-725

[3] A critical review on Chagas disease chemotherapy [J].

Coura, JR ;

de Castro, SL .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2002, 97 (01) :3-24

[4] Free radicals in the physiological control of cell function [J].

Dröge, W .

PHYSIOLOGICAL REVIEWS, 2002, 82 (01) :47-95

[5] Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage [J].

Enanga, B ;

Ariyanayagam, MR ;

Stewart, ML ;

Barrett, MP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (10) :3368-3370

[6] Glutathione in cancer biology and therapy [J].

Estrela, JM ;

Ortega, A ;

Obrador, E .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2006, 43 (02) :143-181

[7] INVIVO EFFECTS OF DIFLUOROMETHYLORNITHINE ON TRYPANOTHIONE AND POLYAMINE LEVELS IN BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI [J].

FAIRLAMB, AH ;

HENDERSON, GB ;

BACCHI, CJ ;

CERAMI, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 24 (02) :185-191

[8] Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi [J].

Faundez, M ;

Pino, L ;

Letelier, P ;

Ortiz, C ;

López, R ;

Seguel, C ;

Ferreira, J ;

Pavani, M ;

Morello, A ;

Maya, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) :126-130

[9] THIRTEENFOLD INCREASE OF CHROMOSOMAL-ABERRATIONS NON-RANDOMLY DISTRIBUTED IN CHAGASIC CHILDREN TREATED WITH NIFURTIMOX [J].

GORLA, NB ;

LEDESMA, OS ;

BARBIERI, GP ;

LARRIPA, IB .

MUTATION RESEARCH, 1989, 224 (02) :263-267

[10] Biologic and pharmacologic regulation of mammalian glutathione synthesis [J].

Griffith, OW .

FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 (9-10) :922-935

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