Viral load in breast milk correlates with transmission of human cytomegalovirus to preterm neonates, but lactoferrin concentrations do not

被引：34

作者：

van der Strate, BWA

Harmsen, MC

Schäfer, P

Swart, PJ

The, TH

Jahn, G

Speer, CP

Meijer, DKF

Hamprecht, K

机构：

[1] Univ Groningen, Inst Drug Explorat GUIDE, Dept Pharmacokinet & Drug Delivery, Ctr Pharm, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Dept Clin Immunol, NL-9713 GZ Groningen, Netherlands

[3] Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Dept Pathol & Lab Med, NL-9713 GZ Groningen, Netherlands

[4] Univ Hamburg, Krankenhaus Eppendorf, Inst Med Mikrobiol & Immunol, D-20246 Hamburg, Germany

[5] Univ Tubingen Hosp, Inst Med Virol & Epidemiol Viral Dis, D-72076 Tubingen, Germany

[6] Univ Wurzburg, Childrens Hosp, D-97080 Wurzburg, Germany

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2001年 / 8卷 / 04期

关键词：

D O I：

10.1128/CDLI.8.4.818-821.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In vitro, lactoferrin (LF) strongly inhibits human cytomegalovirus (HCMV), which led us to hypothesize that in vivo HCMV might also be inhibited in secretions with high LF concentrations. In breast milk, high viral loads observed as high viral DNA titers tended to coincide with higher LF levels. However, the LF Levels did not correlate to virus transmission to preterm infants. The viral load in the transmitting group was highest compared to the nontransmitting group. We conclude that viral load in breast milk is an important factor for transmission of the virus.

引用

页码：818 / 821

页数：4

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