DNA polymerase selectivity: Sugar interactions monitored with high-fidelity nucleotides

被引：0
作者：
Summerer, D [1 ]
Marx, A [1 ]
机构：
[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 19期
关键词：
bioorganic chemistry; DNA polymerases; DNA recognition; DNA replication; nucleotides;
D O I：
10.1002/1521-3773(20011001)40:19<3693::AID-ANIE3693>3.0.CO;2-O
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Do enzyme - sugar interactions contribute to DNA-polymerase fidelity? With the novel chemical probes 1 (R=CH3)2), which are used by a DNA polymerase more selectively than the natural counterpart (R=H), insights are obtained into the influence of enzyme - sugar interactions on the selectivity of the enzyme.
引用
收藏
页码：3693 / +
页数：4
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