Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds

被引：45

作者：

Heublein, Hannes ^{[1
]}

Bader, Augustinus ^{[1
]}

Giri, Shibashish ^{[1
]}

机构：

[1] Univ Leipzig, Ctr Biotechnol & Biomed, Dept Cell Tech & Appl Stem Cell Biol, Fac Med, Deutsch Pl 5, D-04103 Leipzig, Germany

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 06期

关键词：

HUMAN BONE-MARROW; NITRIC-OXIDE SYNTHASE; GROWTH-FACTOR-BETA; NEUTRAL ENDOPEPTIDASE ACTIVITY; STROMAL CELLS; MATRIX-METALLOPROTEINASES; MONONUCLEAR-CELL; INCREASED ANGIOGENESIS; ENDOTHELIAL-CELLS; MESENCHYMAL CELLS;

D O I：

10.1016/j.drudis.2015.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetic wounds remain a global unsolved problem and the cost of diabetes-related amputations and diabetic wound treatment is approximately US$3 billion and US$9 billion per year, respectively. Diabetic foot ulcers (DFUs) occur in 15% of all patients with diabetes and precede 84% of all diabetes-related lower leg amputations. Currently, there is no satisfying treatment for these hard-to-heal-wounds. However, as we discuss here, experimental preclinical evidence for the successful use of adult stem cell therapies for diabetic wounds gives new hope for the development of effective treatments for use in the clinic.

引用

页码：703 / 717

页数：15

共 147 条

[1] Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice [J].

Amin, Ali H. ;

Abd Elmageed, Zakaria Y. ;

Nair, Devika ;

Partyka, Megan I. ;

Kadowitz, Philip J. ;

Belmadani, Souad ;

Matrougui, Khalid .

LABORATORY INVESTIGATION, 2010, 90 (07) :985-996

[2] Neutral endopeptidase activity is increased in the skin of subjects with diabetic ulcers [J].

Antezana, MA ;

Sullivan, SR ;

Usui, ML ;

Gibran, NS ;

Spenny, ML ;

Larsen, JA ;

Ansel, JC ;

Bunnett, NW ;

Olerud, JE .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (06) :1400-1404

[3] The role of matrix metalloproteinases in wound healing [J].

Armstrong, DG ;

Jude, EB .

JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 2002, 92 (01) :12-18

[4] Promising Role of ANGPTL4 Gene in Diabetic Wound Healing [J].

Arya, Awadhesh K. ;

Tripathi, Kamlakar ;

Das, Parimal .

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, 2014, 13 (01) :58-63

[5] Interactive Role of Trauma Cytokines and Erythropoietin and Their Therapeutic Potential for Acute and Chronic Wounds [J].

Bader, Augustinus ;

Lorenz, Katrin ;

Richter, Anja ;

Scheffler, Katja ;

Kern, Larissa ;

Ebert, Sabine ;

Giri, Shibashish ;

Behrens, Maria ;

Dornseifer, Ulf ;

Macchiarini, Paolo ;

Machens, Hans-Guenther .

REJUVENATION RESEARCH, 2011, 14 (01) :57-66

[6] Human CD133+ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling [J].

Barcelos, Luciola S. ;

Duplaa, Cecile ;

Kraenkel, Nicolle ;

Graiani, Gallia ;

Invernici, Gloria ;

Katare, Rajesh ;

Siragusa, Mauro ;

Meloni, Marco ;

Campesi, Ilaria ;

Monica, Manuela ;

Simm, Andreas ;

Campagnolo, Paola ;

Mangialardi, Giuseppe ;

Stevanato, Lara ;

Alessandri, Giulio ;

Emanueli, Costanza ;

Madeddu, Paolo .

CIRCULATION RESEARCH, 2009, 104 (09) :1095-U199

[7] Growth factors and cytokines in wound healing [J].

Barrientos, Stephan ;

Stojadinovic, Olivera ;

Golinko, Michael S. ;

Brem, Harold ;

Tomic-Canic, Marjana .

WOUND REPAIR AND REGENERATION, 2008, 16 (05) :585-601

[8] Rapid healing of a therapy-refractory diabetic foot after transplantation of autologous bone marrow stem cells [J].

Bartsch, T ;

Brehm, M ;

Falke, T ;

Kögler, G ;

Wernet, P ;

Strauer, BE .

MEDIZINISCHE KLINIK, 2005, 100 (10) :676-680

[9] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[10] Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice [J].

Bitto, Alessandra ;

Altavilla, Domenica ;

Pizzino, Gabriele ;

Irrera, Natasha ;

Pallio, Giovanni ;

Colonna, Michele R. ;

Squadrito, Francesco .

BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (09) :2300-2307

← 1 2 3 4 5 6 7 8 9 10 →