Influence of acetate- vs. lactate-containing fluid bolus therapy on acid-base status, electrolytes, and plasma lactate in dogs

被引:3
作者
Klein-Richers, Ute [1 ]
Heitland, Annika [2 ]
Hartmann, Katrin [1 ]
Doerfelt, Rene [1 ]
机构
[1] Ctr Clin Vet Med, Clin Small Anim Med, LMU Munich, Munich, Germany
[2] AniCura Tierklin Haar GmbH, Haar, Germany
关键词
balanced crystalloid solutions; acid-base disorders; hyperlactatemia; metabolic acidosis; canine; HEMORRHAGIC-SHOCK; PASSIVE RECOVERY; SPRINT EXERCISE; NORMAL SALINE; DOUBLE-BLIND; L-MALATE; RESUSCITATION; INFUSION; RINGERS; LIVER;
D O I
10.3389/fvets.2022.903091
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
ObjectiveAcetate- and lactate-containing fluids influence the acid-base and electrolyte status. This prospective, randomized, clinical study compared two balanced crystalloid solutions regarding their influence on acid-base status, electrolytes, and lactate values, when given to dogs as a resuscitation bolus of 30 mL/kg. Material and methodsOne hundred client-owned dogs presenting to the emergency service with signs of fluid deficits were randomly assigned to receive an intravenous bolus of 30 mL/kg of either a lactate- (LAC), or an acetate-containing solution (ACET). Before and after the bolus, vital parameters were assessed, and a venous blood gas analysis was performed. ResultsBoth solutions performed equally well in decreasing the heart rate (ACET: -10 +/- 27 bpm, LAC: -12 +/- 30 bpm; p = 0.737). The acetate-containing solution caused a significant decrease in plasma lactate levels (p = 0.016), anion gap (p < 0.001), and potassium (p < 0.001), and a significant increase in chloride (p < 0.001), and ionized calcium (p = 0.014). The lactate-containing solution caused a significant decrease in anion gap (p < 0.001), sodium (p = 0.016), and potassium (p = 0.001), and a significant increase in chloride (p < 0.001). ACET causes a stronger decrease in plasma lactate (p = 0.015), sodium (p = 0.039), potassium (p = 0.006), and an increase in chloride (p < 0.001), and ionized calcium (p = 0.016) compared to LAC. ConclusionBoth solutions caused mild changes in electrolyte concentrations and had minor influence on acid-base status when used for bolus therapy in dogs with fluid deficits. Further studies are needed to evaluate their influence on acid-base status, lactate, and electrolytes when used in larger volumes and for a longer time span.
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页数:11
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