Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

被引：413

作者：

Mishra, Vijay ^{[1
]}

Bansal, Kuldeep K. ^{[2
]}

Verma, Asit ^{[1
]}

Yadav, Nishika ^{[1
]}

Thakur, Sourav ^{[1
]}

Sudhakar, Kalvatala ^{[1
]}

Rosenholm, Jessica M. ^{[2
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[2] Abo Akad Univ, Pharmaceut Sci Lab, Fac Sci & Engn, FIN-20520 Turku, Finland

来源：

PHARMACEUTICS | 2018年 / 10卷 / 04期

基金：

芬兰科学院;

关键词：

solid lipid nanoparticles; cytotoxicity; targeted drug delivery; colloidal nanocarriers; IN-VITRO; CELLULAR UPTAKE; ORAL DELIVERY; PHYSICOCHEMICAL CHARACTERIZATION; CARRIER SYSTEM; FORMULATION; CURCUMIN; CYTOTOXICITY; CANCER; SLN;

D O I：

10.3390/pharmaceutics10040191

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.

引用

页数：21

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