Human Diurnal Preference and Circadian Rhythmicity Are Not Associated with the CLOCK 3111C/T Gene Polymorphism

被引：27

作者：

Chang, Anne-Marie ^{[1
,2
]}

Buch, Alison M. ^{[1
]}

Bradstreet, Dayna S. ^{[1
]}

Klements, David J. ^{[1
]}

Duffy, Jeanne F. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Div Sleep Med, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Div Sleep Med, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 2011年 / 26卷 / 03期

关键词：

chronotype; human circadian rhythms; circadian phase; circadian period; melatonin; POPULATION; AMPLITUDE; SAMPLE; PHASE; SLEEP;

D O I：

10.1177/0748730411402026

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.

引用

页码：276 / 279

页数：4

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