Palladium-catalyzed intermolecular coupling of 2-haloallylic acetates with simple phenols, and sequential formation of benzofuran derivatives through the intramolecular cyclization

被引：7

作者：

Udagawa, Takumi ^{[1
]}

Tsuchi, Yukiko ^{[1
]}

Takehara, Ikuma ^{[1
]}

Kogawa, Masaki ^{[1
]}

Watanabe, Hirotaka ^{[1
]}

Yamamoto, Mitsuaki ^{[1
]}

Tsuji, Hiroaki ^{[1
]}

Kawatsura, Motoi ^{[1
]}

机构：

[1] Nihon Univ, Coll Humanities & Sci, Dept Chem, Setagaya Ku, Tokyo 1568550, Japan

来源：

TETRAHEDRON | 2017年 / 73卷 / 46期

基金：

日本学术振兴会;

关键词：

Palladium; Benzofuran; Cyclization; Phenol; Allylic compounds; 1,3-DISUBSTITUTED ALLYLIC ESTERS; UNACTIVATED INTERNAL ALKYNES; ONE-POT SYNTHESIS; TRIFLUOROMETHYL GROUP; REGIOSELECTIVE SYNTHESIS; PROPARGYLIC CARBONATES; 2,3,3-TRIFLUOROALLYLIC CARBONATES; 2,3-DISUBSTITUTED BENZOFURANS; SUBSTITUTED 2,3-DIHYDROFURANS; 2-FLUOROALLYLIC ACETATES;

D O I：

10.1016/j.tet.2017.10.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We accomplished the synthesis of 2-substituted benzofuran derivatives by the palladium-catalyzed reaction of 2-haloallylic acetates with simple phenols in the presence of a base. The reaction proceeded through the intermolecular attack of the nucleophile on the central carbon atom of the pi-allyl group, carbon-halogen bond cleavage, and sequential intramolecular cyclization. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：6573 / 6579

页数：7

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