A new synthetic pathway based on one-pot sequential aza-Michael addition and photoCuAAC click reactions

被引：5

作者：

Yin, Boyang ^{[1
]}

Croutxe-Barghorn, Celine ^{[1
]}

Delaite, Christelle ^{[1
]}

Allonas, Xavier ^{[1
]}

机构：

[1] Univ Haute Alsace, Lab Macromol Photochem & Engn, 3 Rue Alfred Werner, F-68093 Mulhouse, France

来源：

RSC ADVANCES | 2019年 / 9卷 / 09期

关键词：

TRANSFER RADICAL POLYMERIZATION; 1,3-DIPOLAR CYCLOADDITION; HETEROGENEOUS CATALYST; ORGANIC AZIDES; EFFICIENT; CUAAC; COMPLEXES; REDUCTION; CHEMISTRY; SPECTRA;

D O I：

10.1039/c8ra10011j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A solvent-free process is described for the synthesis of tailor-made molecules from a one-pot, two-step approach combining aza-Michael addition and photoinduced copper(I) catalysed azide-alkyne (photo-CuAAC) reactions. After the first reaction between an amine and an acrylate, cycloaddition between an azide and an alkyne is activated by light irradiation in the presence of a copper complex. The kinetics of the aza-Michael addition and photo-CuAAC reaction were investigated by liquid state H-1 NMR spectroscopy and real-time Fourier transform infrared spectroscopy. This new process represents a well-defined spatio-temporal pathway to the synthesis of bespoke intermediate molecules for various applications.

引用

页码：4824 / 4831

页数：8

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