Calcipotriol plus betamethasone dipropionate scalp formulation is effective and well tolerated in the treatment of scalp psoriasis: A phase II study

被引：50

作者：

Buckley, Colin ^{[1
]}

Hoffmann, Vibeke ^{[2
]}

Shapiro, Jerry ^{[4
]}

Saari, Seppo ^{[5
]}

Cambazard, Frederic ^{[6
]}

Milsgaard, Mette ^{[3
]}

机构：

[1] Waterford Reg Hosp Ardkeen, Dept Dermatol, Waterford, Ireland

[2] LEO Pharma AS, Clin Operat, Bellerup, Denmark

[3] LEO Pharma AS, Dept Biostat, Bellerup, Denmark

[4] Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 1M9, Canada

[5] Med Recept Ctr, Policlin Dermatol, Turku, Finland

[6] CHU St Etienne, Hop Nord, Serv Dermatol, St Etienne, France

来源：

DERMATOLOGY | 2008年 / 217卷 / 02期

关键词：

betamethasone dipropionate plus calcipotriol; scalp formulation; phase II study; scalp psoriasis; topical treatment;

D O I：

10.1159/000130425

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: There is a need for more effective therapy for scalp psoriasis. Objective: To assess the efficacy and safety of a 2-compound scalp formulation including calcipotriol and betamethasone dipropionate in the treatment of scalp psoriasis. Methods: Patients (n=218) with scalp psoriasis were randomized to treatment with the 2-compound scalp formulation (n=108) or betamethasone dipropionate in the same vehicle (n=110). The treatments were applied once daily on the scalp for up to 8 weeks. Results: The 2-compound scalp formulation showed a significantly higher efficacy than betamethasone dipropionate on the total sign score at the end of treatment (p=0.042)and after 2 weeks (p=0.005). Conclusion: The calcipotriol plus betamethasone dipropionate scalp formulation was superior to betamethasone dipropionate in the same vehicle when used once daily for up to 8 weeks in the treatment of scalp psoriasis. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：107 / 113

页数：7

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