Characteristics of youth at high risk for bipolar disorder compared to youth with bipolar I or II disorder

被引:7
作者
Weintraub, Marc J. [1 ]
Schneck, Christopher D. [2 ]
Walshaw, Patricia D. [1 ]
Chang, Kiki D.
Singh, Manpreet K. [3 ]
Axelson, David A. [4 ,5 ]
Birrnaher, Boris [6 ]
Miklowitz, David J. [1 ]
机构
[1] Univ Calif Los Angeles, UCLA Semel Inst, Los Angeles, CA USA
[2] Univ Colorado, Dept Psychiat, Anschutz Med Campus, Aurora, CO USA
[3] Stanford Univ, Sch Med, Psychiat & Behav Sci, Stanford, CA 94305 USA
[4] Nationwide Childrens Hosp, Dept Psychiat, Columbus, OH USA
[5] Ohio State Univ, Columbus, OH 43210 USA
[6] Univ Pittsburgh, Dept Psychiat, Med Ctr, Pittsburgh, PA USA
关键词
SCHOOL-AGE-CHILDREN; SPECTRUM DISORDERS; STAGING MODEL; EARLY-ONSET; ADOLESCENTS; PREDICTORS; RELIABILITY; SCHIZOPHRENIA; PHENOMENOLOGY; PREVALENCE;
D O I
10.1016/j.jpsychires.2020.01.010
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Significant efforts have been undertaken to characterize the phenomenology of the high-risk period for bipolar disorder (BD) through the examination of youth at familial risk (i.e., having a first- or second-degree relative with BD) or clinical high risk for the disorder (i.e., youth with BD Not Otherwise Specified [NOS] or major depressive disorder [MDD]). However, little is known about the phenomenology of youth at both familial and clinical high risk for BD. In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n = 145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disorder/conduct disorder. Manic symptom severity and psychosocial functioning were progressively more impaired consistent with diagnostic severity: BD I > BD II > BD-NOS > MDD. Nonetheless, HR youth exhibited depressive symptom severity that was comparable to adolescents with BD I. These results provide further support for the high rates of anxiety disorders and premorbid dysfunction in addition to active mood symptoms for youth at risk for BD, and suggest anxiety is an important phenomenological characteristic and treatment target in the high-risk period.
引用
收藏
页码:48 / 53
页数:6
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