Electrically Silent Kv Subunits: Their Molecular and Functional Characteristics

被引：67

作者：

Bocksteins, Elke ^{[1
]}

Snyders, Dirk J. ^{[1
]}

机构：

[1] Univ Antwerp, Dept Biomed Sci, Lab Mol Biophys Physiol & Pharmacol, B-2020 Antwerp, Belgium

来源：

PHYSIOLOGY | 2012年 / 27卷 / 02期

关键词：

CHANNEL ALPHA-SUBUNITS; GATED K+ CHANNELS; KV2.1 POTASSIUM CHANNEL; CONE DYSTROPHY; TETRAMERIZATION DOMAIN; SURFACE EXPRESSION; VOLTAGE SENSOR; KCNV2; GENE; MUTATIONS; STOICHIOMETRY;

D O I：

10.1152/physiol.00023.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Electrically silent voltage-gated potassium (KvS) alpha-subunits do not form homotetramers but heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in which the KvS subunits modulate the Kv2 current. This poses intriguing questions into the molecular mechanisms by which these KvS subunits cannot form functional homotetramers, why they only interact with Kv2 subunits, and how they modulate the Kv2 current.

引用

页码：73 / 84

页数：12

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