SYNTHESIS AND ANTIINFLAMMATORY AND ANALGESIC ACTIVITY OF 1-(2-AMINOETHYL)-5-ARYL-4-ACYL-3-HYDROXY-3-PYRROLIN-2-ONES

被引：43

作者：

Gein, V. L. ^{[1
]}

Yushkov, V. V. ^{[1
]}

Kasimova, N. N. ^{[1
]}

Shuklina, N. S. ^{[1
]}

Vasil'eva, M. Yu ^{[1
]}

Gubanova, M. V. ^{[1
]}

机构：

[1] Perm State Pharmaceut Acad, Perm, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2005年 / 39卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

Methyl; Ester; Organic Chemistry; Aldehyde; Methyl Ester;

D O I：

10.1007/s11094-006-0006-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4,5-Disubstituted 1-(2-aminoethyl)-3-hydroxy-3-pyrrolin-2-ones have been synthesized via reactions of acylpyruvic acid methyl esters with a mixture of an aromatic aldehyde and ethylenediamine. Some of the synthesized compounds display pronounced antiinflammatory and analgesic activity at a relatively low toxicity.

引用

页码：484 / 487

页数：4