Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista

被引：37

作者：

Wang, Kairong ^{[1
]}

Yan, Jiexi ^{[1
]}

Chen, Ru ^{[1
]}

Dang, Wen ^{[1
]}

Zhang, Bangzhi ^{[1
]}

Zhang, Wei ^{[1
]}

Song, Jingjing ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Sch Life Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ANTIBIOTICS; SELECTIVITY; SEQUENCE; MPI; DNA;

D O I：

10.1128/AAC.05995-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The extensive use of antibiotics in medicine, the food industry, and agriculture has resulted in the frequent emergence of multidrug-resistant bacteria, which creates an urgent need for new antibiotics. it is now widely recognized that antimicrobial peptides (AMPs) could play a promising role in fighting multidrug-resistant bacteria. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and studied its action mode of antibacterial activity. Our results revealed that polybia-CP has potent antibacterial activity against both Gram-positive and Gram-negative bacteria. The results from both the real bacterial membrane and the in vitro model membrane showed that polybia-CP is membrane active and that its action target is the membrane of bacteria. It is difficult for bacteria to develop resistance to polybia-CP, which may thus offer a new strategy for defending against resistant bacteria in medicine and the food and farming industries.

引用

页码：3318 / 3323

页数：6

共 30 条

[1] Antimicrobial peptides derived from hen egg lysozyme with inhibitory effect against Bacillus species [J].