Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease

被引：41

作者：

Spekhorst, Lieke M. ^{[1
,2
]}

Imhann, Floris ^{[1
,2
]}

Festen, Eleonora A. M. ^{[1
,2
]}

van Bodegraven, Ad A. ^{[3
]}

de Boer, Nanne K. H. ^{[3
]}

Bouma, Gerd ^{[3
]}

Fidder, Herma H. ^{[4
]}

D'Haens, Geert ^{[5
]}

Hoentjen, Frank ^{[6
]}

Hommes, Daan W. ^{[7
]}

de Jong, Dirk J. ^{[6
]}

Lowenberg, Mark ^{[5
]}

Maljaars, P. W. Jeroen ^{[8
]}

van der Meulen-de Jong, Andrea E. ^{[8
]}

Oldenburg, Bas ^{[4
]}

Pierik, Marieke J. ^{[9
]}

Ponsioen, Cyriel Y. ^{[5
]}

Stokkers, Pieter C. ^{[10
]}

Verspaget, Hein W. ^{[8
]}

Visschedijk, Marijn C. ^{[1
,2
]}

van der Woude, C. Janneke ^{[11
]}

Dijkstra, Gerard ^{[1
]}

Weersma, Rinse K. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[4] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[5] Amsterdam Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[6] Radboud Univ Nijmegen Med Ctr, Dept Gastroenterol & Hepatol, Nijmegen, Netherlands

[7] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA

[8] Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands

[9] Univ Med Ctr Maastricht, Dept Gastroenterol & Hepatol, Maastricht, Netherlands

[10] St Lucas Andreas Ziekenhuis, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[11] Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands

来源：

BMJ OPEN | 2017年 / 7卷 / 11期

关键词：

ULCERATIVE-COLITIS; CROHNS-DISEASE; EXTRAINTESTINAL MANIFESTATIONS; SUSCEPTIBILITY LOCI; RISK-FACTORS; POPULATION; SMOKING; CLASSIFICATION; ASSOCIATION; INCREASES;

D O I：

10.1136/bmjopen-2017-016695

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose The Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Moreover, we aim to provide a complete overview of the content of the Dutch IBD Biobank. Participants Since 2007, every patient with IBD treated in one of the eight Dutch university medical centres is asked to participate in the Dutch IBD Biobank in which 225 standardised IBD-related data items and biomaterials, such as serum, DNA, biopsies and a stool sample, are collected. Findings to date As of June 2014, the Dutch IBD Biobank had enrolled 3388 patients with IBD: 2118 Crohn's disease (62.5%), 1190 ulcerative colitis (35.1%), 74 IBD-unclassified (2.2%) and 6 IBD-indeterminate (0.2%). The inclusion of patients with IBD is ongoing. The quality of the biomaterials is good and serum, DNA and biopsies have been used in newly published studies. Future plans The genotyping (750 000 genetic variants) of all participants of the Dutch IBD Biobank is currently ongoing, enabling more genetic research. In addition, all participants will start reporting disease activity and outcome measures using an online platform and mobile app.

引用

页数：14

共 33 条

[1] Epidemiology and risk factors for IBD [J].

Ananthakrishnan, Ashwin N. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2015, 12 (04) :205-217

[2] Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[3]

[Anonymous], 1996, SCAND J GASTROENTERO, V31, P362

[4]

Bernstein CN, 2001, AM J GASTROENTEROL, V96, P1116

[5] East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort [J].

Burisch, J. ;

Pedersen, N. ;

Cukovic-Cavka, S. ;

Brinar, M. ;

Kaimakliotis, I. ;

Duricova, D. ;

Shonova, O. ;

Vind, I. ;

Avnstrom, S. ;

Thorsgaard, N. ;

Andersen, V. ;

Krabbe, S. ;

Dahlerup, J. F. ;

Salupere, R. ;

Nielsen, K. R. ;

Olsen, J. ;

Manninen, P. ;

Collin, P. ;

Tsianos, E. V. ;

Katsanos, K. H. ;

Ladefoged, K. ;

Lakatos, L. ;

Bjornsson, E. ;

Ragnarsson, G. ;

Bailey, Y. ;

Odes, S. ;

Schwartz, D. ;

Martinato, M. ;

Lupinacci, G. ;

Milla, M. ;

De Padova, A. ;

D'lnca, R. ;

Beltrami, M. ;

Kupcinskas, L. ;

Kiudelis, G. ;

Turcan, S. ;

Tighineanu, O. ;

Mihu, I. ;

Magro, F. ;

Barros, L. F. ;

Goldis, A. ;

Lazar, D. ;

Belousova, E. ;

Nikulina, I. ;

Hernandez, V. ;

Martinez-Ares, D. ;

Almer, S. ;

Zhulina, Y. ;

Halfvarson, J. ;

Arebi, N. .

GUT, 2014, 63 (04) :588-597

[6]

Centres NF of UM, COLL DAT SOURC DUTCH

[7] Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study [J].

Cleynen, Isabelle ;

Boucher, Gabrielle ;

Jostins, Luke ;

Schumm, L. Philip ;

Zeissig, Sebastian ;

Ahmad, Tariq ;

Andersen, Vibeke ;

Andrews, Jane M. ;

Annese, Vito ;

Brand, Stephan ;

Brant, Steven R. ;

Cho, Judy H. ;

Daly, Mark J. ;

Dubinsky, Marla ;

Duerr, Richard H. ;

Ferguson, Lynnette R. ;

Franke, Andre ;

Gearry, Richard B. ;

Goyette, Philippe ;

Hakonarson, Hakon ;

Halfvarson, Jonas ;

Hov, Johannes R. ;

Huang, Hailang ;

Kennedy, Nicholas A. ;

Kupcinskas, Limas ;

Lawrance, Ian C. ;

Lee, James C. ;

Satsangi, Jack ;

Schreiber, Stephan ;

Theatre, Emilie ;

van der Meulen-de Jong, Andrea E. ;

Weersma, Rinse K. ;

Wilson, David C. ;

Parkes, Miles ;

Vermeire, Severine ;

Rioux, John D. ;

Mansfield, John ;

Silverberg, Mark S. ;

Radford-Smith, Graham ;

McGovern, Dermot P. B. ;

Barrett, Jeffrey C. ;

Lees, Charlie W. .

LANCET, 2016, 387 (10014) :156-167

[8] Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomised controlled trial [J].

de Jong, Marin J. ;

van der Meulen-de Jong, Andrea E. ;

Romberg-Camps, Marielle J. ;

Becx, Marco C. ;

Maljaars, Jeroen P. ;

Cilissen, Mia ;

van Bodegraven, Ad A. ;

Mahmmod, Nofel ;

Markus, Tineke ;

Hameeteman, Wim M. ;

Dijkstra, Gerard ;

Masclee, Ad A. ;

Boonen, Annelies ;

Winkens, Bjorn ;

van Tubergen, Astrid ;

Jonkers, Daisy M. ;

Pierik, Marie J. .

LANCET, 2017, 390 (10098) :959-968

[9] Whole-genome sequence variation, population structure and demographic history of the Dutch population [J].

Francioli, Laurent C. ;

Menelaou, Andronild ;

Pulit, Sara L. ;

Van Dijk, Freerk ;

Palamara, Pier Francesco ;

Elbers, Clara C. ;

Neerincx, Pieter B. T. ;

Ye, Kai ;

Guryev, Victor ;

Kloosterman, Wigard P. ;

Deelen, Patrick ;

Abdellaoui, Abdel ;

Van Leeuwen, Elisabeth M. ;

Van Oven, Mannis ;

Vermaat, Martijn ;

Li, Mingkun ;

Laros, Jeroen F. J. ;

Karssen, Lennart C. ;

Kanterakis, Alexandros ;

Amin, Najaf ;

Hottenga, Jouke Jan ;

Lameijer, Eric-Wubbo ;

Kattenberg, Mathijs ;

Dijkstra, Martijn ;

Byelas, Heorhiy ;

Van Settenl, Jessica ;

Van Schaik, Barbera D. C. ;

Bot, Jan ;

Nijman, Isaac J. ;

Renkens, Ivo ;

Marscha, Tobias ;

Schonhuth, Alexander ;

Hehir-Kwa, Jayne Y. ;

Handsaker, Robert E. ;

Polak, Paz ;

Sohail, Mashaal ;

Vuzman, Dana ;

Hormozdiari, Fereydoun ;

Van Enckevort, David ;

Mei, Hailiang ;

Koval, Vyacheslav ;

Moed, Ma-Tthijs H. ;

Van der Velde, K. Joeri ;

Rivadeneira, Fernando ;

Estrada, Karol ;

Medina-Gomez, Carolina ;

Isaacs, Aaron ;

McCarroll, Steven A. ;

Beekrnan, Marian ;

De Craen, Anton J. M. .

NATURE GENETICS, 2014, 46 (08) :818-825

[10] Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci [J].

Franke, Andre ;

McGovern, Dermot P. B. ;

Barrett, Jeffrey C. ;

Wang, Kai ;

Radford-Smith, Graham L. ;

Ahmad, Tariq ;

Lees, Charlie W. ;

Balschun, Tobias ;

Lee, James ;

Roberts, Rebecca ;

Anderson, Carl A. ;

Bis, Joshua C. ;

Bumpstead, Suzanne ;

Ellinghaus, David ;

Festen, Eleonora M. ;

Georges, Michel ;

Green, Todd ;

Haritunians, Talin ;

Jostins, Luke ;

Latiano, Anna ;

Mathew, Christopher G. ;

Montgomery, Grant W. ;

Prescott, Natalie J. ;

Raychaudhuri, Soumya ;

Rotter, Jerome I. ;

Schumm, Philip ;

Sharma, Yashoda ;

Simms, Lisa A. ;

Taylor, Kent D. ;

Whiteman, David ;

Wijmenga, Cisca ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Cohen, Albert ;

Colombel, Jean-Frederick ;

Cottone, Mario ;

Stronati, Laura ;

Denson, Ted ;

De Vos, Martine ;

D'Inca, Renata ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Florin, Tim ;

Franchimont, Denis ;

Gearry, Richard ;

Glas, Juergen ;

Van Gossum, Andre .

NATURE GENETICS, 2010, 42 (12) :1118-+

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