Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells

被引：143

作者：

Curtin, Joshua C. ^{[1
]}

Lorenzi, Matthew V. ^{[1
]}

机构：

[1] Bristol Myers Squibb, Oncol Drug Discovery Res & Dev, Princeton, NJ 08540 USA

来源：

ONCOTARGET | 2010年 / 1卷 / 07期

关键词：

oncotarget; cancer; stem cells; wnt; drug discovery; FRIZZLED-RELATED PROTEIN; SMALL-MOLECULE INHIBITOR; ACUTE MYELOID-LEUKEMIA; BETA-CATENIN; COLORECTAL-CANCER; HEDGEHOG PATHWAY; COLON-CANCER; MONOCLONAL-ANTIBODY; MEDIATED TRANSCRIPTION; SELF-RENEWAL;

D O I：

10.18632/oncotarget.191

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) represent a unique subset of cells within a tumor that possess self-renewal capacity and pluripotency, and can drive tumor initiation and maintenance. First identified in hematological malignancies, CSCs are now thought to play an important role in a wide variety of solid tumors such as NSCLC, breast and colorectal cancer. The role of CSCs in driving tumor formation illustrates the dysregulation of differentiation in tumorigenesis. The Wnt, Notch and Hedgehog (HH) pathways are developmental pathways that are commonly activated in many types of cancer. While substantial progress has been made in developing therapeutics targeting Notch and HH, the Wnt pathway has remained an elusive therapeutic target. This review will focus on the clinical relevance of the Wnt pathway in CSCs and tumor cell biology, as well as points of therapeutic intervention and recent advances in targeting Wnt/beta-catenin signaling.

引用

页码：563 / 577

页数：15

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