Differential persistence of neutralizing antibody against SARS-CoV-2 in post immunized Bangladeshi population

被引：3

作者：

Roy, Dipa ^{[1
]}

Rahman, Md Mosfequr ^{[2
]}

Chaity, Arnaba Saha ^{[1
]}

Abu Reza, Md ^{[3
]}

Haque, Ariful ^{[1
]}

机构：

[1] Univ Rajshahi, Inst Biol Sci, Mol Pathol Lab, Rajshahi 6205, Bangladesh

[2] Univ Rajshahi, Dept Populat Sci & Human Resource Dev, Rajshahi 6205, Bangladesh

[3] Univ Rajshahi, Dept Genet Engn & Biotechnol, Mol Biol & Prot Sci Lab, Rajshahi 6205, Bangladesh

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

CORONAVIRUS; INFECTION; SPIKE;

D O I：

10.1038/s41598-022-18302-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Development of effective vaccines have been immensely welcomed by the world to prevent the transmission of SARS-CoV-2. However, the duration and clinical implications of antibody-mediated natural immunity in SARS-CoV-2 have not been adequately elucidated alongside some other immune system transforming factors. In a cohort study, we measured NAb titer following the 2nd immunization dosage of the CoviShield (AZD1222) vaccine. The enzyme-linked immunoassay was used to look for SARS-CoV-2-specific NAb. We measured NAb at 30 days after the 2nd dosage of immunization and > 96% titer was detected in 42.9% of subjects, but only 5.1% of subjects retained the same level after 180 days. The median NAb titer dropped significantly, from 92% at 30 days to 58% at 180 days (p < 0.001). Besides, there were significant differences observed in NAb titer after 180 days by age, sex, COVID-19 infection, tobacco use, and asthma patients. However, SARS-CoV-2 infection along with two dosages of immunization upheld NAb titer (p < 0.001) even at the end of the study period.

引用

页数：11

共 50 条

[21] A community study of neutralizing antibodies against SARS-CoV-2 in China [J].

Lv, Yitong ;

Huang, Lei ;

Wang, Junhu ;

He, Hui ;

Song, Libo ;

He, Jia ;

Xu, Lida ;

Yu, Changyuan ;

Mei, Ying ;

Gao, Qi .

FRONTIERS IN IMMUNOLOGY, 2023, 14

[22] Potently neutralizing and protective human antibodies against SARS-CoV-2 [J].

Zost, Seth J. ;

Gilchuk, Pavlo ;

Case, James Brett ;

Binshtein, Elad ;

Chen, Rita E. ;

Nkolola, Joseph P. ;

Schafer, Alexandra ;

Reidy, Joseph X. ;

Trivette, Andrew ;

Nargi, Rachel S. ;

Sutton, Rachel E. ;

Suryadevara, Naveenchandra ;

Martinez, David R. ;

Williamson, Lauren E. ;

Chen, Elaine C. ;

Jones, Taylor ;

Day, Samuel ;

Myers, Luke ;

Hassan, Ahmed O. ;

Kafai, Natasha M. ;

Winkler, Emma S. ;

Fox, Julie M. ;

Shrihari, Swathi ;

Mueller, Benjamin K. ;

Meiler, Jens ;

Chandrashekar, Abishek ;

Mercado, Noe B. ;

Steinhardt, James J. ;

Ren, Kuishu ;

Loo, Yueh-Ming ;

Kallewaard, Nicole L. ;

McCune, Broc T. ;

Keeler, Shamus P. ;

Holtzman, Michael J. ;

Barouch, Dan H. ;

Gralinski, Lisa E. ;

Baric, Ralph S. ;

Thackray, Larissa B. ;

Diamond, Michael S. ;

Carnahan, Robert H. ;

Crowe, James E., Jr. .

NATURE, 2020, 584 (7821) :443-+

[23] The development of neutralizing antibodies against SARS-CoV-2 and their common features [J].

Liu, Liu Daisy ;

Lian, Chaoyang ;

Yeap, Leng-Siew ;

Meng, Fei-Long .

JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 12 (12) :980-986

[24] A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug [J].

Liu, Qianyun ;

Lu, Yuchi ;

Cai, Chenguang ;

Huang, Yanyan ;

Zhou, Li ;

Guan, Yanbin ;

Fu, Shiying ;

Lin, Youyou ;

Yan, Huan ;

Zhang, Zhen ;

Li, Xiang ;

Yang, Xiuna ;

Yang, Haitao ;

Guo, Hangtian ;

Lan, Ke ;

Chen, Yu ;

Hou, Shin-Chen ;

Xiong, Yi .

CELL DEATH & DISEASE, 2024, 15 (06)

[25] Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants [J].

Li, Tingting ;

Zhou, Bingjie ;

Luo, Zhipu ;

Lai, Yanling ;

Huang, Suqiong ;

Zhou, Yuanze ;

Li, Yaning ;

Gautam, Anupriya ;

Bourgeau, Salome ;

Wang, Shurui ;

Bao, Juan ;

Tan, Jingquan ;

Lavillette, Dimitri ;

Li, Dianfan .

FRONTIERS IN MICROBIOLOGY, 2022, 13

[26] Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection [J].

Lau, Eric H. Y. ;

Hui, David S. C. ;

Tsang, Owen T. Y. ;

Chan, Wai-Hung ;

Kwan, Mike Y. W. ;

Chiu, Susan S. ;

Cheng, Samuel M. S. ;

Ko, Ronald Lw ;

Li, John K. C. ;

Chaothai, Sara ;

Tsang, Chi H. ;

Poon, Leo L. M. ;

Peiris, Malik .

ECLINICALMEDICINE, 2021, 41

[27] Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants [J].

Qu, Yuanyuan ;

Zhang, Xueyan ;

Wang, Meiyu ;

Sun, Lina ;

Jiang, Yongzhong ;

Li, Cheng ;

Wu, Wei ;

Chen, Zhen ;

Yin, Qiangling ;

Jiang, Xiaolin ;

Liu, Yang ;

Li, Chuan ;

Li, Jiandong ;

Ying, Tianlei ;

Li, Dexin ;

Zhan, Faxian ;

Wang, Youchun ;

Guan, Wuxiang ;

Wang, Shiwen ;

Liang, Mifang .

VIROLOGICA SINICA, 2021, 36 (05) :934-947

[28] SARS-CoV-2 structural features may explain limited neutralizing-antibody responses [J].

Bachmann, Martin F. ;

Mohsen, Mona O. ;

Zha, Lisha ;

Vogel, Monique ;

Speiser, Daniel E. .

NPJ VACCINES, 2021, 6 (01)

[29] Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy [J].

Li, Lin ;

Matsui, Yusuke ;

Prahl, Mary K. ;

Cassidy, Arianna G. ;

Golan, Yarden ;

Jigmeddagva, Unurzul ;

Ozarslan, Nida ;

Lin, Christine Y. ;

Buarpung, Sirirak ;

Gonzalez, Veronica J. ;

Chidboy, Megan A. ;

Basilio, Emilia ;

Lynch, Kara L. ;

Song, Dongli ;

Jegatheesan, Priya ;

Rai, Daljeet S. ;

Govindaswami, Balaji ;

Needens, Jordan ;

Rincon, Monica ;

Myatt, Leslie ;

Taha, Taha Y. ;

Montano, Mauricio ;

Ott, Melanie ;

Greene, Warner C. ;

Gaw, Stephanie L. .

NPJ VACCINES, 2024, 9 (01)

[30] Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans [J].

Vanshylla, Kanika ;

Di Cristanziano, Veronica ;

Kleipass, Franziska ;

Dewald, Felix ;

Schommers, Philipp ;

Gieselmann, Lutz ;

Gruell, Henning ;

Schlotz, Maike ;

Ercanoglu, Meryem S. ;

Stumpf, Ricarda ;

Mayer, Petra ;

Zehner, Matthias ;

Heger, Eva ;

Johannis, Wibke ;

Horn, Carola ;

Suarez, Isabelle ;

Jung, Norma ;

Salomon, Susanne ;

Eberhardt, Kirsten Alexandra ;

Gathof, Birgit ;

Faetkenheuer, Gerd ;

Pfeifer, Nico ;

Eggeling, Ralf ;

Augustin, Max ;

Lehmann, Clara ;

Klein, Florian .

CELL HOST & MICROBE, 2021, 29 (06) :917-+

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