ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis

被引：42

作者：

Vespa, L ^{[1
]}

Couvillion, M ^{[1
]}

Spangler, E ^{[1
]}

Shippen, DE ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 18期

关键词：

telomere; DNA damage; telomerase; chromosome fusion; plant;

D O I：

10.1101/gad.1333805

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Here we examine the function of ATM and ATR at telomeres in Arabidopsis. Although plants lacking ATM or ATR display wild-type telomere length homeostasis, chromosome end protection is compromised in atm atr mutants. Moreover, atm tert Arabidopsis experience an abrupt, early onset of genome instability, arguing that ATM is required for protection of short telomeres. ATR, by contrast, is required for maintenance of telomeric DNA as telomere shortening is dramatically accelerated in atr tert mutants relative to tert plants. Thus, ATM and ATR make essential and distinct contributions to chromosome end protection and telomere maintenance in higher eukaryotes.

引用

页码：2111 / 2115

页数：5